Results 81 to 90 of about 3,186 (156)

Watermelon: setup and validation of an in silico fragment-based approach

Journal of Enzyme Inhibition and Medicinal Chemistry
We present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target’s ...
Miriana Di Stefano, Salvatore Galati, Lisa Piazza, Francesca Gado, Carlotta Granchi, Marco Macchia, Antonio Giordano, Tiziano Tuccinardi, Giulio Poli   +8 more
doaj   +1 more source

Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2021
openaire   +2 more sources

Monoacylglycerol lipase (MAGL) [PDF]

Science-Business eXchange, 2011
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MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity

Theranostics
Rationale: Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD). Tubular cell injury plays a pivotal role in renal fibrosis. Commonly, injured tubular cells exhibit significant lipid accumulation. However, the underlying mechanisms remain poorly understood.
Zhou, Shan, Ling, Xian, Zhu, Jielin, Liang, Ye, Feng, Qijian, Xie, Chao, Li, Jiemei, Chen, Qiyan, Chen, Shuangqin, Miao, Jinhua, Zhang, Mengyao, Li, Zhiru, Shen, Weiwei, Li, Xiaolong, Wu, Qinyu, Wang, Xiaoxu, Liu, Ruiyuan, Wang, Cheng, Hou, Fan Fan, Kong, Yaozhong, Liu, Youhua, Zhou, Lili   +21 more
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Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration.

PLoS ONE
Neuroinflammation, a hallmark of neurodegenerative diseases, is associated with neuronal cell loss and cognitive dysfunction. Monoacylglycerol lipase (MAGL) is involved in neuroinflammation in the brain via the degradation of endocannabinoid 2 ...
Naoto Arimura, Chie Maeda, Kazunobu Aoyama, Namiko Yamaguchi, Ayumu Sugiura, Yasuko Takahashi, Ryouta Maeda, Tatsuya Ando, Makoto Kamata, Hideki Matsui, Maiko Tanaka   +10 more
doaj   +1 more source

Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.)

BMC Plant Biology
Background Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.
Zhibin Zhou, Yao Chen, Mengyuan Yan, Shuqi Zhao, Feifei Li, Shuxun Yu, Zhen Feng, Libei Li   +7 more
doaj   +1 more source

Monoacylglycerol lipase (MAGL) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Upravljanje sustavom vodene magle upotrebom programabilnih logičkih kontrolera

, 2023
This thesis describes the functioning of programmable logic controllers and fire extinguishing systems in the ship's engine room using water mist. The basic concept of a programmable logic controller is presented with its architecture, types, and different programming methods.
openaire   +1 more source

Monoglyceride lipase (MGLL; MAGL) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Monoacylglycerol lipase (MAGL; MGL) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source