Results 91 to 100 of about 406 (129)

Persistent deficiency of circulating mucosal-associated invariant T (MAIT) cells in ANCA-associated vasculitis

Journal of Autoimmunity, 2016
Mucosal associated invariant T cells (MAIT) and innate lymphoid cells (ILCs) have immunoregulatory functions at mucosal sites and have been involved in various inflammatory and autoimmune diseases. The aim of this study was to assess their frequencies in blood in ANCA-associated vasculitis (AAV).The frequencies and function of MAIT cells, ILCs, γδT ...
Cecile Braudeau, Mohamed HAMIDOU, Régis Josien   +2 more
exaly   +5 more sources

Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients [PDF]

Cancer Immunology, Immunotherapy, 2021
AbstractMucosal-associated invariant T (MAIT) cells are unconventional T cells recognizing microbial metabolites, presented by the invariant MR1 protein. Upon activation, MAIT cells rapidly secrete cytokines and exert cytotoxic functions, and may thus be highly relevant also in tumor immunity.
Yvonne Wettergren, Marianne Quiding Järbrink, Louis Szeponik   +2 more
exaly   +3 more sources

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Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset

Microbes and Infection, 2005
Besides mainstream TCRalphabeta T cells harboring a very diverse repertoire, two subsets display an evolutionarily conserved invariant repertoire. This striking conservation indicates important and unique functions. CD1d-restricted NK-T cells expressing an invariant Valpha14 TCRalpha chain have been implicated in microbial and tumor responses as well ...
Treiner, Emmanuel, Duban, Livine, Moura, Ivan Cruz, Hansen, Ted, Gilfillan, Susan, Lantz, Olivier   +5 more
openaire   +2 more sources

Phenotypic and functional characterization of bovine mucosal associated invariant T (MAIT) cells

The Journal of Immunology, 2020
Abstract Mucosal associated invariant T (MAIT) cells are innate-like T cells that are prevalent in the blood and tissues of many mammalian species. MAIT cells recognize small metabolites derived from the riboflavin pathway that are presented by the highly conserved MHC-related protein-1 (MR1).
Suyeon Hong, Jodi L McGill
openaire   +1 more source

The frequency and dynamics of CD4+ mucosal‐associated invariant T (MAIT) cells in active pulmonary tuberculosis

Cellular Immunology, 2021
MAIT cells are unconventional innate-like T lymphocytes contributing to host immune protection against Mycobacteria tuberculosis (Mtb) infection. CD4- MAIT cells play a major role in immune protection against tuberculosis (TB), however, the role of CD4+ MAIT cells was elusive due to their low abundance.
Kunlong, Xiong, Wenwen, Sun, Hongxiu, Wang, Jianping, Xie, Bo, Su, Lin, Fan   +5 more
openaire   +2 more sources

Dual role of mucosal-associated invariant T cells (MAIT) in asthma

Journal of Asthma
Mucosal-associated invariant T cells (MAIT) are the predominant type of innate-like T cells in humans, and they represent a unique subset of microbiota-dependent invariant T cells. This Commentary reviews recent clinical studies and animal model research elucidating the multifaceted roles of MAIT cells in asthma.A literature search was performed using ...
M Asghar, Pasha, Rawaa, Alnabulsi, Aiden, Wan, Russell J, Hopp, Qi, Yang   +4 more
openaire   +2 more sources

Defining the role of mucosal-associated invariant T (MAIT) cells in B cell help

The Journal of Immunology, 2020
Abstract Pathogen-associated diarrheal diseases account for over 1.6 million deaths annually, yet the number of effective mucosal vaccines remains limited. An exciting potential target for mucosal vaccine adjuvants are mucosal-associated invariant T (MAIT) cells.
Owen Jensen, Shubhanshi Trivedi, Jeremy D Meier, Daniel T Leung   +3 more
openaire   +1 more source

Title: Human mucosal-associated invariant T (MAIT) cells in inflamed tissues

The Journal of Immunology, 2017
Abstract Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites via a semi-invariant T cell receptor (TCR) presented by MHC-like molecule MR1. Once activated, MAIT cells are a potent effector population with cytotoxic and pro-inflammatory properties.
Julia D Berkson, Chloe Slicter, Mukta Dutta, Haley Oberbillig, Martin Prlic   +4 more
openaire   +1 more source

The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

Organic & Biomolecular Chemistry, 2019
Glyco-analogues of MR1 ligands can bind MR1 and activate MAIT cells at levels similar to 5-OP-RU.
Chriselle D. Braganza, Kensuke Shibata, Aisa Fujiwara, Chihiro Motozono, Koh-Hei Sonoda, Sho Yamasaki, Bridget L. Stocker, Mattie S. M. Timmer   +7 more
openaire   +2 more sources

How MR1 Presents a Pathogen Metabolic Signature to Mucosal-Associated Invariant T (MAIT) Cells

Trends in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes restricted by the antigen (Ag)-presenting molecule MHC class I (MHC I)-related protein 1 (MR1). The Ags presented by MR1 are vitamin B-related Ags (VitBAgs), 'building-block' metabolites of riboflavin that are synthesized by a range of microbes.
Hamish E.G. McWilliam, Jose A. Villadangos   +1 more
openaire   +2 more sources