Results 71 to 80 of about 406 (129)

Dysregulation of Peripheral Blood B Cells and Natural Killer Cells Is Associated With Myocarditis in Idiopathic Inflammatory Myopathies

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective Idiopathic inflammatory myopathies (IIMs), or myositis, are a group of systemic autoimmune diseases leading to proximal muscle weakness. Myocarditis is a major cause of adverse outcomes. Yet, we know very little about the underlying immunologic processes that are driving myocarditis in the context of IIMs. Methods We performed single‐cell RNA
Carolina Duque, Sylvie T. Rousseau, Zuzana Bologna, Monica R. Mugnier, Luigi Adamo, Julie J. Paik   +5 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

MAIT Cells in Liver Disease

Cells
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in the human liver which can provide antimicrobial defense, amplify inflammatory processes and mediate tissue repair and fibrosis depending on microenvironmental cues ...
Adiba I. Azad, Florencia Gutierrez, Gregory J. Gores   +2 more
doaj   +1 more source

Biological functions and therapeutic applications of human mucosal-associated invariant T cells

Journal of Biomedical Science
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells ...
Ying Fang, Yuning Chen, Siyue Niu, Zibai Lyu, Yanxin Tian, Xinyuan Shen, Yan-Ruide Li, Lili Yang   +7 more
doaj   +1 more source

Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer

OncoImmunology
Mucosal-associated invariant T (MAIT) cells constitute one of the most numerous unconventional T cell subsets, and are characterized by rapid release of Th1- and Th17-associated cytokines and increased cytotoxic functions following activation. MAIT cells
Patrik Sundström, Nikita Dutta, William Rodin, Andreas Hallqvist, Sukanya Raghavan, Marianne Quiding Järbrink   +5 more
doaj   +1 more source

Mucosal-associated invariant T (MAIT) cells are reduced and dysfunctional in acute melioidosis

Scientific Reports
Abstract Burkholderia pseudomallei (BP), the causative agent of melioidosis, is a major cause of sepsis in Southeast Asia, especially in people with diabetes mellitus (DM). The role of Mucosal-associated invariant T (MAIT) cells; innate-like T cells important for antibacterial immunity; in ...
Fazle Rabbi Chowdhury, Martha Zewdie, Priyanka Abraham, Srija Moulik, Hadiza Adebowale, Jennifer Hill, Md Robed Amin, Lovely Barai, Md Rokibul Hasan, Ayako Kurioka, Patpong Rongkard, Direk Limmathurotsakul, Nicholas P. J. Day, Parinya Chamnan, Paul Klenerman, Chris B. Willberg, Barbara Kronsteiner, Susanna J. Dunachie   +17 more
openaire   +1 more source

Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus.

PLoS Pathogens, 2014
Non-conventional T lymphocytes constitute a special arm of the immune system and act as sentinels against pathogens at mucosal surfaces. These non-conventional T cells (including mucosal-associated invariant T [MAIT] cells, gamma delta [γδ] T cells, and ...
Stoyan Ivanov, Christophe Paget, François Trottein   +2 more
doaj   +1 more source

Mucosal-Associated Invariant T (MAIT) Cells in Skin Immunity: Metabolic Regulation, Tissue Adaptation, and Roles in Skin Inflammation and Disease

JID Innovations
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that recognize microbial-derived vitamin B metabolites presented by the nonpolymorphic MR1 (major histocompatibility complex class I–related protein).
Namya Nanda, Chloe Kim, Ishita Jain, Charlene Cai, Martin P. Alphonse   +4 more
doaj   +1 more source

MAIT cells protect against sterile lung injury

Cell Reports
Summary: Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in
Xiawei Zhang, Shuailin Li, Wojciech Lason, Maria Greco, Paul Klenerman, Timothy S.C. Hinks   +5 more
doaj   +1 more source

Human MAIT cells undergo clonal selection and expansion during thymic maturation and aging

Experimental and Molecular Medicine
Mucosal-associated invariant T (MAIT) cells harbor conserved T cell receptors (TCRs) recognizing riboflavin metabolites, yet exhibit substantial diversity similar to conventional memory T cells.
Myeong-seok Lee, Suyeong Park, Jung-Hwan Choi, Seon Yong Bae, Han Suk Ryu, Min-Sung Kim, Jae Gun Kwak, You Jeong Lee   +7 more
doaj   +1 more source