Results 51 to 60 of about 406 (129)

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19 [PDF]

, 2020
ABSTRACT Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts ...
Chen Yu, Sejiro Littleton, Nicholas Giroux, Rose Mathew, Shengli Ding, Joan Kalnitsky, Elizabeth W. Petzold, Hong Chung, Grecia Rivera Palomino, Tomer Rotstein, Rui Xi, Emily R. Ko, Ephraim L. Tsalik, Gregory D. Sempowski, Thomas N. Denny, Thomas W. Burke, Micah T. McClain, Christopher W. Woods, Xiling Shen, Daniel R. Saban   +19 more
openaire   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

MAIT cell counts are associated with the risk of hospitalization in COPD

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways.
Terezia Pincikova, Tiphaine Parrot, Lena Hjelte, Marieann Högman, Karin Lisspers, Björn Ställberg, Christer Janson, Andrei Malinovschi, Johan K. Sandberg   +8 more
doaj   +1 more source

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

Cell Proliferation, EarlyView.
Schematic diagram for the experimental design for adaptome immune repertoire analysing Dampness ZHENG across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis. ABSTRACT Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide.
Lipeng Tang, Maojie Wang, Yuhong Yan, Shumin Qin, Youbang Liang, Danni Yao, Liyan Mei, Hao Deng, Shuyan Ye, Xiumin Chen, Kaixin Gao, Xirun Zheng, Taohua Liu, Xinmin Qiu, Song Li, Xinjie Yu, Wenjing Pan, Shaogang Huang, Zhe Wang, Runyue Huang, Guangjuan Zheng, Chuanjian Lu   +21 more
wiley   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Notch signaling regulates function of human mucosal-associated invariant T (MAIT) cells

Asian Pacific Journal of Allergy and Immunology
Notch signaling plays an important role in the development of T lymphocytes and regulates their effector functions. The regulatory roles of Notch signaling on T cells have been intensely investigated, but whether it involves in effector functions of mucosal-associated invariant T (MAIT) cells has never been reported.To elucidate the expression profiles
Pimpayao, Sodsai, Siriwan, Klinchanhom, Nattiya, Hirankarn, Rangsima, Reantragoon, Tanapat, Palaga   +4 more
openaire   +2 more sources

High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia

Biomedical Papers
Aims. Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues.
Ivana Karlova Zubata, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Jan Novak   +4 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules [PDF]

Oncotarget, 2019
Mucosal-associated invariant T (MAIT) cells all express a semi-invariable T cell receptor recognizing microbial metabolites presented on the MHC class I-like molecule MR1. Upon activation, they rapidly secrete cytokines and increase their cytotoxic potential.
Sundström, P., Szeponik, L., Ahlmanner, F., Sundquist, M., Wong, J.S.B., Lindskog, E.B., Gustafsson, B., Quiding-Järbrink, M.   +7 more
openaire   +2 more sources