Results 31 to 40 of about 406 (129)

Differential location of NKT and MAIT cells within lymphoid tissue

Scientific Reports, 2022
Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with specific ...
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey   +14 more
doaj   +1 more source

Circulating CD8+ mucosal‐associated invariant T cells correlate with improved treatment responses and overall survival in anti‐PD‐1‐treated melanoma patients

Clinical & Translational Immunology, 2022
Objectives While much of the research concerning factors associated with responses to immune checkpoint inhibitors (ICIs) has focussed on the contributions of conventional peptide‐specific T cells, the role of unconventional T cells, such as mucosal ...
Victoria M Vorwald, Dana M Davis, Robert J Van Gulick, Robert J Torphy, Jessica SW Borgers, Jared Klarquist, Kasey L Couts, Carol M Amato, Dasha T Cogswell, Mayumi Fujita, Moriah J Castleman, Timothy Davis, Catherine Lozupone, Theresa M Medina, William A Robinson, Laurent Gapin, Martin D McCarter, Richard P Tobin   +17 more
doaj   +1 more source

MAIT cells and the microbiome

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ...
Maisha F. Jabeen, Maisha F. Jabeen, Timothy S. C. Hinks, Timothy S. C. Hinks   +3 more
doaj   +1 more source

Mucosal-associated invariant T (MAIT) cells: new players in anti-bacterial immunity

Frontiers in Immunology, 2014
Mucosal-associated invariant T (MAIT) cells are an innate-like T cell population involved in antibacterial immunity. In humans, MAIT cells are abundant, comprising ~ 10% of the CD8+ T cell compartment in blood.
James E Ussher, James E Ussher, Paul eKlenerman, Paul eKlenerman, Chris Bjørnsen Willberg, Chris Bjørnsen Willberg   +5 more
doaj   +1 more source

Mucosal-associated invariant T cells recognize a tumor-derived metabolite in the DNA synthesis pathway

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells recognize metabolite-derived ligands, but the identity of such ligands in the context of cancer remains poorly defined.
Yanqi Xue, Yuka Yamada, Rikako Suzuki, Brenda Luong, Shotaro Fujii, Keisuke Nakata, Masatomo Takahashi, Yoshihiro Izumi, Chihiro Fukui, Ryosuke Takasaki, Francois Legoux, Shinsuke Inuki, Shinsuke Inuki, Daisuke Motooka, Emi Ito, Bridget L. Stocker, Mattie S. M. Timmer, Takashi Shimizu, Yasumasa Matsuoka, Jun’ichi Mano, Koji Tamada, Koji Tamada, Makoto Furutani-Seiki, Kei Sakamoto, Koh-Hei Sonoda, Olivier Lantz, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Sho Yamasaki, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +33 more
doaj   +1 more source

Circulating and tumor-infiltrating mucosal associated invariant T (MAIT) cells in colorectal cancer patients [PDF]

Scientific Reports, 2016
AbstractMucosal associated invariant T (MAIT) cells are important for immune defense against infectious pathogens and regulate the pathogenesis of various inflammatory diseases. However, their roles in the development of colorectal cancer (CRC) are still unclear. This study examined the phenotype, distribution, clinical relevance and potential function
Limian Ling, Yuyang Lin, Wenwen Zheng, Sen Hong, Xiuqi Tang, Pingwei Zhao, Ming Li, Jingsong Ni, Chenguang Li, Lei Wang, Yanfang Jiang   +10 more
openaire   +2 more sources

Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells, a novel subpopulation of innate-like T cells that express an invariant T cell receptor (TCR)α chain and a diverse TCRβ chain, can recognize a distinct set of small molecules, vitamin B metabolites, derived ...
Xingxing Xiao, Xingxing Xiao, Jianping Cai, Jianping Cai   +3 more
doaj   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Mucosa associated invariant T and natural killer cells in active and budesonide treated collagenous colitis patients

Frontiers in Immunology, 2022
IntroductionCollagenous colitis (CC) is an inflammatory bowel disease, which usually responds to budesonide treatment. Our aim was to study the immunological background of the disease.MethodsAnalyses of peripheral and mucosal MAIT (mucosa associated ...
Niki Daferera, Sofia Nyström, Sofia Nyström, Henrik Hjortswang, Simone Ignatova, Maria C. Jenmalm, Magnus Ström, Andreas Münch   +7 more
doaj   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source