Results 11 to 20 of about 406 (129)

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies. [PDF]

PLoS ONE, 2016
The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are ...
Yifang Gao, William Rae, Keseva Ananth Ramakrishnan, Gabriela Barcenas-Morales, Rainer Döffinger, Efrem Eren, Saul N Faust, Christian H Ottensmeier, Anthony P Williams   +8 more
doaj   +4 more sources

B cells modulate mucosal associated invariant T cell (MAIT) immune responses [PDF]

Frontiers in Immunology, 2014
A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings
Rosangela eSalerno-Goncalves, Tasmia eRezwan, Marcelo B. Sztein   +2 more
doaj   +3 more sources

Mucosal‐associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders [PDF]

The FASEB Journal, 2018
ABSTRACT The disruption of systemic immune homeostasis is a key mediator in the progression of cardiometabolic diseases (CMDs). We aimed to extend knowledge regarding the clinical relevance of CMD‐associated variation of circulating mucosal‐associated invariant T (MAIT) cell abundance and to explore underlying ...
Touch, Sothea, Assmann, Karen, Aron-Wisnewsky, Judith, Marquet, Florian, Rouault, Christine, Fradet, Magali, Mosbah, Héléna, Consortium, Metacardis, Isnard, Richard, Helft, Gérard, Lehuen, Agnès, Poitou, Christine, Clément, Karine, André, Sébastien   +13 more
openaire   +3 more sources

Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

eLife, 2020
Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands. We investigated MAIT cells during clinical and experimental sepsis, and their contribution to host responses. In experimental sepsis, MAIT-
Shubhanshi Trivedi, Daniel Labuz, Cole P Anderson, Claudia V Araujo, Antoinette Blair, Elizabeth A Middleton, Owen Jensen, Alexander Tran, Matthew A Mulvey, Robert A Campbell, J Scott Hale, Matthew T Rondina, Daniel T Leung   +12 more
openaire   +4 more sources

Characterization of Human Mucosal‐associated Invariant T (MAIT) Cells

Current Protocols in Immunology, 2019
AbstractMucosal‐associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility complex (MHC) class I–like molecule MHC‐related protein 1 (MR1). MAIT cells are found throughout the body, especially in human blood and liver.
Souter, Michael N.T., Loh, Liyen, Li, Shihan, Meehan, Bronwyn S., Gherardin, Nicholas A., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., Kedzierska, Katherine, Pellicci, Daniel G., Chen, Zhenjun, Kjer-Nielsen, Lars, Corbett, Alexandra J., McCluskey, James, Eckle, Sidonia B. G.   +14 more
openaire   +6 more sources

Characterization and Purification of Mouse Mucosal‐Associated Invariant T (MAIT) Cells

Current Protocols in Immunology, 2019
AbstractThis unit describes the utility of various mouse models of infection and immunization for studying mucosal‐associated invariant T (MAIT) cell immunity: MAIT cells can be isolated from the lungs (or from other tissues/organs) and then identified and characterized by flow cytometry using MR1 tetramers in combination with a range of antibodies ...
Chen, Z, Wang, H, D'Souza, C, Koay, H-F, Meehan, B, Zhao, Z, Pediongco, T, Shi, M, Zhu, T, Wang, B, Kjer-Nielsen, L, Eckle, SBG, Rossjohn, J, Fairlie, DP, Godfrey, DI, Strugnell, RA, McCluskey, J, Corbett, AJ   +17 more
openaire   +6 more sources

166 Mucosal-associated invariant T-cells (MAIT) in pancreatic cancer

Regular and young investigator award abstracts, 2020
Background Immunotherapy has changed the standard of care for multiple cancers; however, its efficacy is limited. Chemotherapy and radiation had little effect in pancreatic ductal adenocarcinoma (PDAC) outcome1 in patients with metastatic disease, hence the urgency for new effective courses of treatment. Increasing evidence suggests mucosal-associated
Jéssica Kamiki, Patrícia António, Pedro Noronha, Carolina Condeço, Georgia Paraschoudi, Eric De Sousa, Andreia Maia, Mireia Castillo-Martin, Antonio Beltran, Carlos Carvalho, Joana Lérias, Markus Maeurer   +11 more
openaire   +2 more sources

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases [PDF]

Clinical and Experimental Immunology, 2014
Summary Inflammatory bowel diseases are characterized by a deregulated immune response targeting the gut bacterial flora. Mucosal-associated invariant T (MAIT) cells are major histocompatibility complex (MHC) class Ib-restricted innate-like lymphocytes with anti-bacterial functions. They display an effector/memory phenotype and are found
N-E, Serriari, M, Eoche, L, Lamotte, J, Lion, M, Fumery, P, Marcelo, D, Chatelain, A, Barre, E, Nguyen-Khac, O, Lantz, J-L, Dupas, E, Treiner   +11 more
openaire   +2 more sources

Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

Nature Communications, 2021
Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages ...
Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza   +18 more
doaj   +1 more source

Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help [PDF]

Journal of Leukocyte Biology, 2017
Abstract Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset, restricted by the nonclassic MHC class I-related protein MR1 and enriched at mucosal sites. Human studies have shown an association between MAIT cells and pathogen-specific antibody responses.
Michael S, Bennett, Shubhanshi, Trivedi, Anita S, Iyer, J Scott, Hale, Daniel T, Leung   +4 more
openaire   +2 more sources