Results 21 to 30 of about 406 (129)

Mining the multifunction of mucosal-associated invariant T cells in hematological malignancies and transplantation immunity: A promising hexagon soldier in immunomodulatory

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved innate-like T cells capable of recognizing bacterial and fungal ligands derived from vitamin B biosynthesis. Under different stimulation conditions, MAIT cells can display different
Meng-Ge Gao, Xiao-Su Zhao, Xiao-Su Zhao, Xiao-Su Zhao   +3 more
doaj   +1 more source

Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen [PDF]

Veterinary Research, 2010
MHC-related protein 1 (MR1) is a highly conserved MHC class I-like molecule. Human and murine mucosal associated invariant T (MAIT) cells are restricted by MR1 and express an invariant T cell receptor. Even though MR1 protein expression on the cell surface has not been demonstrated in vivo or ex vivo, it is assumed that MR1 presents a bacterial antigen
Goldfinch, N., Reinink, P., Connelly, T., Koets, A.P., Morrison, I., van Rhijn, I.   +5 more
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Human Tissue-Resident Mucosal-Associated Invariant T (MAIT) Cells in Renal Fibrosis and CKD [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement Although mucosal-associated invariant T (MAIT) cells are emerging as a key player in chronic inflammatory diseases, their role in CKD’s hallmark fibrosis is unclear. Using multicolor flow cytometry and immunofluorescence, the authors identified tissue-resident MAIT cells in healthy kidneys and ...
Becker M. P. Law, Ray Wilkinson, Xiangju Wang, Katrina Kildey, Kurt Giuliani, Kenneth W. Beagley, Jacobus Ungerer, Helen Healy, Andrew J. Kassianos   +8 more
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Mucosal-Associated Invariant T Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba, Goh Murayama, Sachiko Miyake   +2 more
doaj   +1 more source

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
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OX40L/OX40 Signal Promotes IL-9 Production by Mucosal MAIT Cells During Helicobacter pylori Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells play a critical role in Helicobacter pylori (H. pylori)-induced gastritis by promoting mucosal inflammation and aggravating mucosal injuries (1, 2).
Siqi Ming, Siqi Ming, Siqi Ming, Mei Zhang, Zibin Liang, Chunna Li, Jianzhong He, Peiyu Chen, Shunxian Zhang, Xiaoli Niu, Shimei Deng, Lanlan Geng, Guoliang Zhang, Sitang Gong, Yongjian Wu, Yongjian Wu   +15 more
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Legionella protection and vaccination mediated by Mucosal Associated Invariant T (MAIT) cells [PDF]

, 2017
Abstract Mucosal associated invariant T (MAIT) cells recognize conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defense, yet their roles in protection against clinically significant pathogens are unknown. Murine
Wang, Huimeng, D’Souza, Criselle, Lim, Xin Yi, Kostenko, Lyudmila, Pediongco, Troi J, Eckle, Sidonia BG, Meehan, Bronwyn S, Wang, Nancy, Li, Shihan, Liu, Ligong, Mak, Jeffrey YW, Fairlie, David P, Iwakura, Yoichiro, Gunnersen, Jennifer M, Stent, Andrew W, Rossjohn, Jamie, Westall, Glen P, Kjer-Nielsen, Lars, Strugnell, Richard A, McCluskey, James, Corbett, Alexandra J, Hinks, Timothy SC, Chen, Zhenjun   +22 more
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AB0139 Role of mucosal-associated invariant t (MAIT) cells in a lupus model [PDF]

Annals of the Rheumatic Diseases, 2017
Background Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. Previously, we have demonstrated that MAIT cells played a protective role against experimental autoimmune encephalomyelitis, an animal model ...
G Murayama, A Chiba, A Nomura, H Amano, K Yamaji, N Tamura, S Miyake   +6 more
openaire   +1 more source

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn   +9 more
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Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease

Journal of Innate Immunity, 2020
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can activate either in response to T-cell receptor (TCR) engagement or through activating cytokines and play an important role in autoimmune disorders.
Jae Kyun Ju, Young-Nan Cho, Ki-Jeong Park, Han Deok Kwak, Hye-Mi Jin, Seon-Young Park, Hyun Soo Kim, Seung-Jung Kee, Yong-Wook Park   +8 more
doaj   +1 more source