Results 81 to 90 of about 406 (129)

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +1 more source

The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes

Frontiers in Immunology
Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by autoreactive CD8+ T cells that destroy insulin-producing pancreatic β-cells. CD8+ T cells are unlikely to be the only cells involved in diabetes.
Devin R. Fraser, Andrew W. Stadnyk, Andrew W. Stadnyk, Andrew W. Stadnyk   +3 more
doaj   +1 more source

Regulation and heterogeneity of human mucosal-associated invariant T (MAIT) cells in blood and liver

, 2020
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like, effector memory T cells, that secrete proinflammatory cytokines and exhibit direct cytotoxic activity. Given their semi-invariant T cell receptor (TCR) and characteristic phenotype, MAIT cells appear as a homogeneous population.
openaire   +2 more sources

Circulating MAIT cells in multiple sclerosis and amyotrophic lateral sclerosis

Frontiers in Immunology
Neurological disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), may be associated with alterations in blood cell composition and phenotype.
Davide De Federicis, Claudia Bassani, Rosaria Rita Chiarelli, Federico Montini, Federico Montini, Antonino Giordano, Antonino Giordano, Federica Esposito, Federica Esposito, Nilo Riva, Nilo Riva, Angelo Quattrini, Vittorio Martinelli, Vittorio Martinelli, Massimo Filippi, Massimo Filippi, Massimo Filippi, Massimo Filippi, Cinthia Farina   +18 more
doaj   +1 more source

Diversity and hallmarks of metabolites surveyed by MR1

Immunobiology
Mucosal-associated invariant T (MAIT) cells are one of the innate T cell subset. They are known to contribute to anti-bacterial response by recognizing bacterial components with invariant TCRs which are presented on a monomorphic antigen presenting ...
Emi Ito, Sho Yamasaki
doaj   +1 more source

Engineering CAR-Mucosal-Associated Invariant T (MAIT) cells for cancer therapy

The advent of chimeric antigen receptor (CAR) technology has revolutionized cancer immunotherapy by empowering T cells to recognize and eliminate tumour cells in a highly specific and efficient manner. In recent years, there has been a heightened interest in harnessing unconventional T cell subsets as potential candidates for CAR-based therapies ...
openaire   +2 more sources

Human neonatal MR1T cells have more diverse TCR repertoires but reduced bacterial recognition than adult MR1T cells

Nature Communications
Bacterial sepsis is a leading cause of neonatal mortality. Pro-inflammatory MR1-restricted T (MR1T) cells may help protect from sepsis by recognizing bacterial pathogens producing the canonical MR1 antigen 5-OP-RU.
Dylan Kain, Wael Awad, G. W. McElfresh, Meghan Cansler, Gwendolyn M. Swarbrick, Kean Chan Yew Poa, Conor McNeice, Gregory Boggy, Katherine H. Rott, Megan D. Null, David M. Lewinsohn, Jamie Rossjohn, Benjamin N. Bimber, Deborah A. Lewinsohn   +13 more
doaj   +1 more source

Implication of MAIT (Mucosal Associated Invariant T) cells in rheumatoid arthritis

Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes capable of producing inflammatory cytokines and cytotoxic molecules. A decrease in their frequency and phenotypic alterations have been reported in several autoimmune diseases.
openaire   +1 more source

Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease

JCI Insight
Adoptive transfer of immunoregulatory cells can prevent or ameliorate graft-versus-host disease (GVHD), which remains the main cause of nonrelapse mortality after allogeneic hematopoietic stem cell transplantation.
Nana Talvard-Balland, Marion Lambert, Mathieu F. Chevalier, Norbert Minet, Marion Salou, Marie Tourret, Armelle Bohineust, Idan Milo, Véronique Parietti, Thomas Yvorra, Gérard Socié, Olivier Lantz, Sophie Caillat-Zucman   +12 more
doaj   +1 more source

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients [PDF]

Viruses, 2021
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure.
Johanna Erber, Dirk H Busch, Christof Winter   +2 more
exaly   +6 more sources