Results 91 to 100 of about 12,732 (162)

Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment

Molecular Oncology, Volume 18, Issue 7, Page 1695-1718, July 2024.
T cells engineered to express chimeric antigen receptors (CAR) are dependent on the transport and utilization of nutrients from the extracellular space, fueling their anti‐tumor activity. Nonetheless, the tumor microenvironment is characterized by a dearth of several key nutrients and alterations in metabolic scavenging systems.
Josquin Moraly, Taisuke Kondo, Mehdi Benzaoui, Justyn DuSold, Sohan Talluri, Marie C. Pouzolles, Christopher Chien, Valérie Dardalhon, Naomi Taylor   +8 more
wiley   +1 more source

Ancient Evolution of Mammarenaviruses: Adaptation via Changes in the L Protein and No Evidence for Host-Virus Codivergence [PDF]

, 2018
The Mammarenavirus genus includes several pathogenic species of rodent-borne viruses. Old World (OW) mammarenaviruses infect rodents in the Murinae subfamily and are mainly transmitted in Africa and Asia; New World (NW) mammarenaviruses are found in ...
Forni, Diego, Pozzoli, Uberto, Uberto Pozzoli, Pontremoli, Chiara, Cagliani, Rachele, Chiara Pontremoli, Manuela Sironi, Diego Forni, Rachele Cagliani, Clerici, Mario, Sironi, Manuela, Mario Clerici   +11 more
core   +1 more source

A broadly adaptable protocol for isolating Kupffer cells from non-model species: application to Mastomys natalensis and its susceptibility to Old World mammarenaviruses

Frontiers in Immunology
BackgroundKupffer cells are specialized, liver-resident macrophages that play central roles in hepatic homeostasis, immune surveillance and pathogen clearance.
Nicolas Corrales, Katharina Hansen-Kant, Angelika Lander, Joseph B. Prescott   +3 more
doaj   +1 more source

A Highly Conserved Leucine in Mammarenavirus Matrix Z Protein Is Required for Z Interaction with the Virus L Polymerase and Z Stability in Cells Harboring an Active Viral Ribonucleoprotein

, 2018
Mammarenaviruses cause chronic infections in their natural rodent hosts. Infected rodents shed infectious virus into excreta. Humans are infected through mucosal exposure to aerosols or direct contact of abraded skin with fomites, resulting in a wide ...
Juan C. de la Torre, Masaharu Iwasaki
core   +1 more source

Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.

PLoS Pathogens, 2018
Several mammalian arenaviruses (mammarenaviruses) cause hemorrhagic fevers in humans and pose serious public health concerns in their endemic regions.
Masaharu Iwasaki, Petra Minder, Yíngyún Caì, Jens H Kuhn, John R Yates, Bruce E Torbett, Juan C de la Torre   +6 more
doaj   +1 more source

Regulation of Tacaribe Mammarenavirus Translation: Positive 5′ and Negative 3′ Elements and Role of Key Cellular Factors [PDF]

, 2017
Mammarenaviruses are enveloped viruses with a bisegmented negative-stranded RNA genome that encodes the nucleocapsid protein (NP), the envelope glycoprotein precursor (GPC), the RNA polymerase (L), and a RING matrix protein (Z).
Alejandra D'Antuono, D'antuono, Alejandra Lorena, Gonzalo de Prat Gay, Foscaldi, Sabrina Andrea, María Gabriela Noval, de Prat Gay, Gonzalo, Noval, María Gabriela, Lopez, Nora Mabel, Luis Scolaro, Sabrina Foscaldi, Nora Lopez, Scolaro, Luis Alberto   +11 more
core   +1 more source

Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters

Viruses, 2018
New World arenaviruses cause fatal hemorrhagic disease in South America. Pirital virus (PIRV), a mammarenavirus hosted by Alston’s cotton rat (Sigmodon alstoni), causes a disease in Syrian golden hamsters (Mesocricetus auratus) (biosafety level-3 ...
Corey L. Campbell, Aaron T. Phillips, Amber Rico, Amanda McGuire, Tawfik A. Aboellail, Sandra Quackenbush, Ken E. Olson, Tony Schountz   +7 more
doaj   +1 more source

The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication

Virology, 2018
Junín arenavirus infections are associated with high levels of interferons in both severe and fatal cases. Upon Junín virus (JUNV) infection a cell signaling cascade initiates, that ultimately attempts to limit viral replication and prevent infection progression through the expression of host antiviral proteins.
Peña Cárcamo, José Rafael, Morell, María Laura, Vázquez, Cecilia Alejandra, Vatansever, Sezen, Upadhyay, Arunkumar S., Överby, Anna K., Cordo, Sandra Myriam, Garcia, Cybele   +7 more
openaire   +3 more sources

The ever-expanding diversity and complexity of the Arenaviridae family

Virulence, 2023
Hinh Ly
doaj   +1 more source

Immunoinformatics analysis to design novel epitope based vaccine candidate targeting the glycoprotein and nucleoprotein of Lassa mammarenavirus (LASMV) using strains from Nigeria

, 2021
Lassa mammarenavirus (LASMV) is responsible for a specific type of acute viral hemorrhagic fever known as Lassa fever. Lack of effective treatments and counter-measures against the virus has resulted in a high mortality rate in its endemic regions ...
Abass Ohilebo Abdulateef
core