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Natural History of Chapare Virus Infection in Strain 13 Guinea Pigs. [PDF]
J Infect DisJohnson DM +4 more
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Pseudotyped Viruses for Mammarenavirus
Advances in Experimental Medicine and Biology, 2023Mammarenaviruses are classified into New World arenaviruses (NW) and Old World arenaviruses (OW). The OW arenaviruses include the first discovered mammarenavirus-lymphocytic choriomeningitis virus (LCMV) and the highly lethal Lassa virus (LASV). Mammarenaviruses are transmitted to human by rodents, resulting in severe acute infections and hemorrhagic ...
Youchun Wang
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Molecular Engineering of a Mammarenavirus with Unbreachable Attenuation
Journal of Virology, 2023Several mammarenaviruses cause severe disease in humans and pose important public health problems in their regions of endemicity. Currently, no FDA-licensed mammarenavirus vaccines are available, and anti-mammarenaviral therapy is limited to an off-label use of ribavirin whose efficacy is controversial.
Luis Martinez-Sobrido +2 more
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Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus
Journal of Virology, 2020 To date, no Food and Drug Administration (FDA)-approved vaccines are available to combat hemorrhagic fever caused by mammarenavirus infections in humans. Treatment of mammarenavirus infections is limited to the off-label use of ribavirin, which is partially effective and associated with significant side effects.
Luis Martinez-Sobrido +2 more
exaly +4 more sources
Mammarenavirus Genetic Diversity and Its Biological Implications
2023Members of the family Arenaviridae are classified into four genera: Antennavirus, Hartmanivirus, Mammarenavirus, and Reptarenavirus. Reptarenaviruses and hartmaniviruses infect (captive) snakes and have been shown to cause boid inclusion body disease (BIBD).
Manuela Sironi +2 more
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Antiviral Research, 2019 Several mammarenaviruses, chiefly Lassa virus (LASV) in Western Africa and Junín virus (JUNV) in the Argentine Pampas, cause severe disease in humans and pose important public health problems in their endemic regions. Moreover, mounting evidence indicates that the worldwide-distributed mammarenavirus lymphocytic choriomeningitis virus (LCMV) is a ...
Arnab Chatterjee, Yingyun Cai
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A Mammarenavirus Close to Lassa Virus in a Patient with Meningoencephalitis
New England Journal of MedicineFranck De Laval +2 more
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Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus
Journal of Molecular Biology, 2017Whitewater Arroyo virus belongs to the "New World" group of mammarenaviruses that reside in rodent reservoirs and are prevalent in North and South Americas. Clades B and A/B of New World mammarenaviruses use transferrin receptor 1 (TfR1) for entry.
Amir, Shimon, Orly, Shani, Ron, Diskin
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Treatment of highly virulent mammarenavirus infections—status quo and future directions
Expert Opinion on Drug DiscoveryMammarenaviruses are negative-sense bisegmented enveloped RNA viruses that are endemic in Africa, the Americas, and Europe. Several are highly virulent, causing acute human diseases associated with high case fatality rates, and are considered to be significant with respect to public health impact or bioterrorism threat.This review summarizes the status
Gabriella Worwa, , Ian Crozier
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Computer-aided rational design of a mRNA vaccine against Guanarito mammarenavirus
Biotechnology LettersGuanarito mammarenavirus (GTOV) is a highly pathogenic virus that leads to Venezuelan hemorrhagic fever (VHF). Despite being a severe disease, there are currently no commercially available drugs or vaccines for its prevention.Here we computationally formulated a mRNA vaccine construct (VC) from the genome of GTOV to produce immunity against its ...
Mohibullah Shah +10 more
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