Results 161 to 170 of about 13,001 (185)

Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses. [PDF]

Acta Pharmacol Sin
Gao X, Wu Y, He XX, Liu GL, Yang HX, Lu J, Zhu XR, Chen XL, Zhao CS, Li HY, Zhang ZF, Yang C, Shen S, Deng F, Xu W, Liu SW, Xiao GF, Pan XY.   +17 more
europepmc   +1 more source

Pathogenesis of Chapare virus in cynomolgus macaques. [PDF]

EMI Anim Environ
Johnson DM, Woolsey C, Agans KN, Borisevich V, Prasad AN, Deer DJ, Dobias NS, Fenton KA, Cross RW, Geisbert TW.   +9 more
europepmc   +1 more source

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Molecular Engineering of a Mammarenavirus with Unbreachable Attenuation

Journal of Virology, 2023
Several mammarenaviruses cause severe disease in humans and pose important public health problems in their regions of endemicity. Currently, no FDA-licensed mammarenavirus vaccines are available, and anti-mammarenaviral therapy is limited to an off-label use of ribavirin whose efficacy is controversial.
Saori Sakabe, Beatrice Cubitt, Luis Martinez-Sobrido   +2 more
exaly   +3 more sources

Pseudotyped Viruses for Mammarenavirus

Advances in Experimental Medicine and Biology, 2023
Mammarenaviruses are classified into New World arenaviruses (NW) and Old World arenaviruses (OW). The OW arenaviruses include the first discovered mammarenavirus-lymphocytic choriomeningitis virus (LCMV) and the highly lethal Lassa virus (LASV). Mammarenaviruses are transmitted to human by rodents, resulting in severe acute infections and hemorrhagic ...
Qianqian, Li, Weijing, Huang, Youchun, Wang   +2 more
exaly   +3 more sources

Development of Reverse Genetics for the Prototype New World Mammarenavirus Tacaribe Virus

Journal of Virology, 2020
To date, no Food and Drug Administration (FDA)-approved vaccines are available to combat hemorrhagic fever caused by mammarenavirus infections in humans. Treatment of mammarenavirus infections is limited to the off-label use of ribavirin, which is partially effective and associated with significant side effects.
Chengjin Ye, Juan Carlos de la Torre, Luis Martinez-Sobrido   +2 more
exaly   +4 more sources

Mammarenavirus Genetic Diversity and Its Biological Implications

2023
Members of the family Arenaviridae are classified into four genera: Antennavirus, Hartmanivirus, Mammarenavirus, and Reptarenavirus. Reptarenaviruses and hartmaniviruses infect (captive) snakes and have been shown to cause boid inclusion body disease (BIBD).
Manuela Sironi, Diego Forni, Juan C. de la Torre   +2 more
openaire   +2 more sources

Reverse genetics approaches for the development of mammarenavirus live-attenuated vaccines

Current Opinion in Virology, 2020
Several mammarenaviruses can cause severe hemorrhagic fever disease with a very high case fatality rate, representing important threats to human health within the viruses' endemic regions. To date, there are no United States (US) Food and Drug Administration (FDA)-licensed vaccines available to combat mammarenavirus infections in humans, and current ...
Chengjin Ye, Luis Martinez-Sobrido, Juan Carlos de la Torre   +2 more
exaly   +4 more sources

Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus

Journal of Molecular Biology, 2017
Whitewater Arroyo virus belongs to the "New World" group of mammarenaviruses that reside in rodent reservoirs and are prevalent in North and South Americas. Clades B and A/B of New World mammarenaviruses use transferrin receptor 1 (TfR1) for entry.
Amir, Shimon, Orly, Shani, Ron, Diskin
openaire   +2 more sources