Results 1 to 10 of about 84,098 (261)

The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation [PDF]

Frontiers in Immunology, 2021
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
Hendrik J. P. van der Zande, Dominik Nitsche, Laura Schlautmann, Bruno Guigas, Sven Burgdorf   +4 more
doaj   +2 more sources

Mannose Ligands for Mannose Receptor Targeting. [PDF]

Int J Mol Sci
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Paurević M, Šrajer Gajdošik M, Ribić R.   +2 more
europepmc   +3 more sources

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition [PDF]

Virulence
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Hong Zhang, Tao Zhu, Wenchun Xu, Bichen Liu, Kaifeng Wu, Yibing Yin, Xuemei Zhang   +6 more
doaj   +2 more sources

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing [PDF]

mAbs
During the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions.
Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel   +7 more
doaj   +2 more sources

Evolution of an expanded mannose receptor gene family. [PDF]

PLoS ONE, 2014
Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B.
Karen Staines, Lawrence G Hunt, John R Young, Colin Butter   +3 more
doaj   +4 more sources

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. [PDF]

PLoS ONE, 2011
Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206
Denarda Dangaj, Karen L Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S Kirby, Raphael Sandaltzopoulos, Daniel J Powell, Antonin Lamazière, Don L Siegel, Claude Wolf, Nathalie Scholler   +10 more
doaj   +1 more source

Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis

BMC Pediatrics, 2021
Introduction The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Noha A. Hassuna, Ebtesam Elgezawy, Suzan O. Mousa, Reem A. AbdelAziz, Reham A. Ibrahem, Wafaa Yousif Abdel Wahed, Khalid A. Nasif, Enas M. Hefzy   +7 more
doaj   +1 more source

Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis

Molecules, 2022
Punicalagin is the most bioactive pomegranate polyphenol with high antioxidant and free-radical scavenging activity and can potentially cure different ailments related to the cardiovascular system.
Ritu Karwasra, Shaban Ahmad, Nagmi Bano, Sahar Qazi, Khalid Raza, Surender Singh, Saurabh Varma   +6 more
doaj   +1 more source

Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature

Revista da Sociedade Brasileira de Medicina Tropical, 2021
We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the
Dewton de Moraes Vasconcelos, Dalton Luís Bertolini, Maurício Domingues Ferreira   +2 more
doaj   +1 more source

Mannosylation of virus-like particles enhances internalization by antigen presenting cells. [PDF]

PLoS ONE, 2014
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses.
Farah Al-Barwani, Sarah L Young, Margaret A Baird, David S Larsen, Vernon K Ward   +4 more
doaj   +1 more source