The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation [PDF]
Frontiers in Immunology, 2021 The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
Hendrik J. P. van der Zande +4 more
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Mannose Ligands for Mannose Receptor Targeting. [PDF]
Int J Mol SciThe mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Paurević M +2 more
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The mannose receptor ligands and the macrophage glycome. [PDF]
Curr Opin Struct Biol, 2022 A unique glycan-binding protein expressed in macrophages and some types of other immune cells is the mannose receptor (MR, CD206). It is an endocytic, transmembrane protein with multiple glycan-binding domains and different specificities in binding glycans.
Cummings RD.
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Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition [PDF]
VirulenceThe detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Hong Zhang +6 more
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Evolution of an expanded mannose receptor gene family. [PDF]
PLoS ONE, 2014 Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B.
Karen Staines +3 more
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Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2021 We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the
Dewton de Moraes Vasconcelos +2 more
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Modulation of mannose receptor activity by proteolysis [PDF]
Biochemical Journal, 1990 Macrophages express a receptor on the cell surface that functions to clear glycoproteins from the extracellular milieu. The activity of this receptor is sensitive to treatment with trypsin. In inflammatory situations, macrophages are activated and exposed to increased levels of extracellular proteases.
Virginia L. Shepherd +3 more
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Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis [PDF]
BMC Pediatrics, 2021 Introduction The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Noha A. Hassuna +7 more
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Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing [PDF]
mAbsDuring the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions.
Julia Baumeister +7 more
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The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity [PDF]
Frontiers in Immunology, 2017 Infection with parasitic helminths affects humanity and animal welfare. Parasitic helminths have the capacity to modulate host immune responses to promote their survival in infected hosts, often for a long time leading to chronic infections.
Irma van Die, Richard D. Cummings
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