Results 1 to 10 of about 170,469 (263)

Identification of the Crucial Gene in Overflow Arteriovenous Fistula by Bioinformatics Analysis

Frontiers in Physiology, 2021
Objective: The aim was to study the preliminary screening of the crucial genes in intimal hyperplasia in the venous segment of arteriovenous (AV) fistula and the underlying potential molecular mechanisms of intimal hyperplasia with bioinformatics ...
Zhengde Zhao, Qining Fu, Liangzhu Hu, Liangzhu Hu, Yangdong Liu, Yangdong Liu   +5 more
doaj   +1 more source

Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function

Frontiers in Cell and Developmental Biology, 2021
BackgroundType 2 diabetes mellitus increases the risk of cardiovascular disease including myocardial infarction (MI). Inflammation and apoptosis have been implicated in the pathophysiology of MI.
Chuang Sun, Guangwei Zeng, Tingting Wang, He Ren, Huixian An, Cheng Lian, Jing Liu, Li Guo, Wei Li   +8 more
doaj   +1 more source

MAPK pathway: Potential role in glioblastoma multiforme

Interdisciplinary Neurosurgery, 2021
Glioblastoma multiforme (GBM) is one of the most aggressive and damaging tumors of the brain. For successful therapy of GBM exact pathways need to be explored for developing effective targeted chemotherapeutic agents.
Kowthavarapu V. Krishna, Sunil Kumar Dubey, Gautam Singhvi, Gaurav Gupta, Prashant Kesharwani   +4 more
doaj   +1 more source

MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

iScience, 2021
Summary: Activation of mitogenic signaling pathways is a common oncogenic driver of many solid tumors including lung cancer. Although activating mutations in the mitogen-activated protein kinase (MAPK) pathway are prevalent in non-small cell lung cancers,
Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen   +15 more
doaj   +1 more source

MAPK Signaling Pathway Is Essential for Female Reproductive Regulation in the Cabbage Beetle, Colaphellus bowringi

Cells, 2022
The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction.
Zijie Huang, Zhong Tian, Yulian Zhao, Fen Zhu, Wen Liu, Xiaoping Wang   +5 more
doaj   +1 more source

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

HMGB3 promotes the malignant phenotypes and stemness of epithelial ovarian cancer through the MAPK/ERK signaling pathway

Cell Communication and Signaling, 2023
Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in ...
Hanlin Ma, Gonghua Qi, Fang Han, Panpan Gai, Jiali Peng, Beihua Kong   +5 more
doaj   +1 more source

Effects of quercetin on granulosa cells from prehierarchical follicles by modulating MAPK signaling pathway in chicken

Poultry Science, 2023
: Quercetin (Que), widely found in a huge variety of plants, plays important roles in ovarian function. However, to data, there have been no reports about Que regulating granulosa cells (GCs) in prehierarchical follicles in chicken.
Manman Shen, Tao Li, Yuan Feng, Ping Wu, Boris Ramos Serrano, Adileidys Ruiz Barcenas, Liang Qu, Weiguo Zhao   +7 more
doaj   +1 more source

Adiponectin impairs chicken preadipocytes differentiation through p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways. [PDF]

PLoS ONE, 2013
Adiponectin is a protein hormone secreted exclusively by adipocytes that plays an important role in the modulation of glucose and lipid metabolism.
Jun Yan, Lu Gan, Di Chen, Chao Sun
doaj   +1 more source

The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression

iScience, 2022
Summary: The mitogen-activated protein kinase (MAPK) intracellular signaling pathway mediates numerous biological processes, including antimicrobial immune response by inducing antimicrobial peptides (AMPs) production.
Jude Juventus Aweya, Kaiying Zhuang, Yiqi Liu, Jiaohong Fan, Defu Yao, Fan Wang, Xiaohan Chen, Shengkang Li, Hongyu Ma, Yueling Zhang   +9 more
doaj   +1 more source