Results 11 to 20 of about 170,469 (263)
MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon, Simon Weonsang Ro
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Organophosphorus Compounds and MAPK Signaling Pathways [PDF]
International Journal of Molecular Sciences, 2020 The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission ...
Tahereh Farkhondeh +5 more
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Understanding MAPK Signaling Pathways in Apoptosis [PDF]
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus.
Yue, Jicheng, López, José M.
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Hesperetin affects osteoclast differentiation via MAPK signaling pathway
Advances in Clinical and Experimental Medicine, 2023 The number and activity of osteoblasts and osteoclasts play an important role in skeletal biology, especially in bone reconstruction. Scientific and rational regulation of osteoclast formation and activity has become a critical strategy aimed at inhibiting the loss of bone mass in the body and alleviating the occurrence of bone diseases.
Jingxian, Fan +8 more
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MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
Journal of Inflammation Research, 2023 The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation.
Yu,Bo +7 more
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ERK/MAPK signalling pathway and tumorigenesis.
Experimental and therapeutic medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, MAPK kinase kinase, MAPK kinase and MAPK, which activate and phosphorylate downstream proteins.
Guo, Yan-Jun +5 more
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MAPKs in development: insights from Dictyostelium signaling pathways [PDF]
BioMolecular Concepts, 2011 AbstractMitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals. MAPK signaling pathways have been associated with the regulation of cell growth, differentiation, and chemotaxis, indicating that MAPKs contribute to a ...
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
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A MAPK pathway mediates ethylene signaling in plants [PDF]
The EMBO Journal, 2003 Ethylene signal transduction involves ETR1, a two-component histidine protein kinase receptor. ETR1 functions upstream of the negative regulator CTR1. The similarity of CTR1 to members of the Raf family of mitogen-activated protein kinase kinase kinases (MAPKKKs) suggested that ethylene signaling in plants involves a MAPK pathway, but no direct ...
Ouaked, Fatma +3 more
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Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats [PDF]
International Neurourology Journal, 2021 Purpose Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein ...
Sang-Hoon Kim +3 more
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DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]
, 2010 To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara +6 more
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