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Role of lipids in the MAPK signaling pathway
Progress in Lipid Research, 2006The mitogen-activated protein kinase (MAPK) signaling pathway is activated in response to a variety of extracellular stimuli such as growth factor stimulation. The best-characterized MAPK pathway involves the sequential activation of Raf, MEK and ERK proteins, capable of regulating the gene expression required for cell proliferation.
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Regulation of MAPK Signaling Pathways Through Immunophilin-ligand Complex
Current Topics in Medicinal Chemistry, 2003It is well established that the immunosuppressive effects of cyclosporin A (CsA) and FK506 (also known as tacrolimus) are mediated through binding to their cognate cellular proteins cyclophilin and FKBP (collectively termed immunophilins), respectively.
Satoshi, Matsuda, Shigeo, Koyasu
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MAPK signaling pathways in eye wounds: Multifunction and cooperation
Experimental Cell Research, 2017As is widely distributed in eukaryotic cells, the mitogen-activated protein kinase (MAPK) signaling pathway family plays an inevitable role in diverse cellular processes, being capable of responding to particular physiological reactions induced by multiple extracellular signals or stimuli, such as protean concentrations, ischemia/reperfusion, and ...
Boyuan, Yao +5 more
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Eimeria tenella induces p38 MAPK signalling pathway
2022Eimeria tenella is an obligate intracellular parasite responsible for avian coccidiosis. As for other apicomplexan parasites, cell invasion and intracellular development are based on apical organelles content discharge, named micronemes and rhoptries (ROP). Some ROP kinases (ROPK) are key virulence factors that hijack host cell signalling pathways.
Ribeiro E Silva, Adeline +8 more
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Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury
Neurochemical Research, 2012The MAPK/ERK/p38 are signal transduction pathways that couple intracellular responses to the external stimuli. Contrary to ERK protein which is part of the survival route, presence of p38 could have an impact on cell injury. Tolerance induced by ischemic preconditioning (IPC) is a phenomenon of tissue adaptation, which results in increased tolerance to
Maria, Kovalska +8 more
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Anoikis Mediated by Stress-Activated MAPK Signaling Pathways
2021The JUN NH2-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) represent a group of signaling enzymes that are collectively named stress-activated MAPKs. Recent studies of epithelial cells have demonstrated that both of these signaling pathways promote detachment-induced cell death (anoikis) in vitro and in vivo.
Nomeda Girnius, Roger J. Davis
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Regulation of cross-talk in yeast MAPK signaling pathways
Current Opinion in Microbiology, 2010MAP kinase (MAPK) modules are conserved three-kinase cascades that serve central roles in intracellular signal transduction in eukaryotic cells. MAPK pathways of different inputs and outputs use overlapping sets of signaling components. In yeast, for example, three MAPK pathways (pheromone response, filamentous growth response, and osmostress ...
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TAB1 Links MAPK Signaling to the p53 Pathway
Cancer Discovery, 2013Abstract TAB1 interacts with MDM2 and regulates p53-mediated cell death in response to cisplatin.
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Regulation of MAPK/JNK signaling pathway and TGF-beta signaling pathway by axin
2014Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. Axin is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by downregulating the β-catenin levels. It also plays an important role in a
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The adenosine pathway in immuno-oncology
Nature Reviews Clinical Oncology, 2020Bertrand Allard +2 more
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