Results 21 to 30 of about 170,469 (263)

Effect of Basigin on the Mitogen Activated Protein Kinase Signaling Pathway and Apoptosis in Qinchuan Cattle Muscle during Postmortem Maturation [PDF]

Shipin Kexue
In order to explore the effects of basigin (BSG) on the mitogen activated protein kinase (MAPK) signaling pathway and apoptosis in Qinchuan cattle muscle during postmortem maturation, the changes in BSG and related differentially expressed proteins were ...
SU Xiaofeng, LI Yalei, LUO Ruiming
doaj   +1 more source

Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]

PLoS ONE, 2014
Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd, Erica Kumala, Laura Anselmi, Nicholas C Brecha, Catia Sternini   +4 more
doaj   +1 more source

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]

, 2016
Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S, Daynac, Mathieu, Grossauer, Stefan, James, C David, Koeck, Katharina, McMahon, Martin, Meyers, Ian D, Murphy, Nicole E, Nicolaides, Theodore P, Petritsch, Claudia K, Phillips, Joanna J, Truffaux, Nathalene, Truong, Albert Y   +12 more
core   +1 more source

An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]

, 2007
Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G., Huang, Jingyu, Jongeward, Gregg, Lauritzen, Amara, Modzelewska, Katarzyna, Moghal, Nadeem, Sternberg, Paul W., Yoon, Charles H.   +7 more
core   +2 more sources

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas [PDF]

, 2016
Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. In a transgenic model of breast cancer, Pten suppression using a
Baselga, J., Bialucha, C. U., Dow, L. E., Ebbesen, S. H., Kastenhuber, E. R., Lowe, S. W., Morse, N., Scaltriti, M., Wen, H. Y.   +8 more
core   +1 more source

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Cancer Cell International, 2022
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho   +10 more
doaj   +1 more source

Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components

mSphere, 2023
Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses.
Matthew D. Vandermeulen, Paul J. Cullen
doaj   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

MAPK/JNK signalling: a potential autophagy regulation pathway [PDF]

Bioscience Reports, 2015
Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations.
Zhou, Yuan-Yuan, Li, Ying, Jiang, Wei-Qin, Zhou, Lin-Fu   +3 more
openaire   +2 more sources

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Journal of Diabetes Research, 2017
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
Lin Luo, Wen-Hua Zhou, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Lin-Dan Ji   +7 more
doaj   +1 more source