Results 31 to 40 of about 170,469 (263)
BMC Bioinformatics, 2022 Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
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The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization [PDF]
International Journal of Molecular Sciences, 2021 Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during
Zuzana Tóthová +5 more
openaire +3 more sources
International Journal of Endocrinology, 2016 Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng +6 more
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MicroRNAs in melanoma development and resistance to target therapy [PDF]
, 2017 microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio +7 more
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Ecotoxicology and Environmental Safety, 2022 Cadmium (Cd) is a highly toxic metal pollutant that can endanger the life and health of animals. Toll-like receptor 4 (TLR4) can result in testicular cell damage by positively regulating mitogen-activated protein kinase (MAPK)/nuclear factor-kappaB (NF ...
Yulong Li +9 more
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Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells [PDF]
, 2015 Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling pathways. We recently characterized an estrogen receptor-positive epithelial murine breast cancer cell
Bal, Elisa Dora +3 more
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A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC [PDF]
, 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data
Barollo, Susi +16 more
core +7 more sources
Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]
, 2019 Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G +2 more
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Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
core +1 more source
Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
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