Results 21 to 30 of about 246,652 (309)

Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]

, 2012
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Djafarzadeh, Roghieh, Hofstetter, Monika, Jaeckel, Carsten, Nelson, Peter J., Notohamiprodjo, Susan, Rieth, Nicole   +5 more
core   +2 more sources

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis. [PDF]

, 2017
During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to ...
Alber, M, Kim, O, Klymenko, Y, Lombard, R, Loughran, E, Stack, MS, Yang, J   +6 more
core   +3 more sources

Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer

Tumor Biology, 2018
Despite gastric cancer being rare nowadays in Western countries, it remains one of the leading causes of cancer death worldwide. The course of the disease varies, so the individual gastric cancer patient’s prognosis is difficult to determine.
Alli Laitinen, Jaana Hagström, Harri Mustonen, Arto Kokkola, Taina Tervahartiala, Timo Sorsa, Camilla Böckelman, Caj Haglund   +7 more
doaj   +1 more source

Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. [PDF]

PLoS ONE, 2013
Rupture of an atherosclerotic plaque is a key event in the development of cardiovascular disorders, in which matrix metalloproteinase-1 (MMP-1) plays a crucial role by degradation of extracellular matrix resulting in plaque instability.
Akinori Tokito, Michihisa Jougasaki, Tomoko Ichiki, Shuichi Hamasaki   +3 more
doaj   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Influence of phase I periodontal therapy on levels of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1

Saudi Dental Journal, 2014
Background: Matrix metalloproteinase-1 (MMP-1) is a member of a family of enzymes that can degrade most extracellular matrix macromolecules. Extracellularly, MMPs are controlled by tissue inhibitors of metalloproteinases (TIMPs) and by mechanisms of pro ...
Pallavi S. Ghodpage, Rajashri A. Kolte, Abhay P. Kolte, Madhur Gupta   +3 more
doaj   +1 more source

Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer [PDF]

, 2016
Oral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can lead to poor clinical outcomes and extensive resource utilisation.
Bowen, J., Gibson, R., Logan, R., Van Sebille, Y., Wardill, H.   +4 more
core   +1 more source

Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1) [PDF]

Journal of Biological Chemistry, 2009
The presence of extensive reciprocal conformational freedom between the catalytic and the hemopexin-like domains of full-length matrix metalloproteinase-1 (MMP-1) is demonstrated by NMR and small angle x-ray scattering experiments. This finding is discussed in relation to the essentiality of the hemopexin-like domain for the collagenolytic activity of ...
BERTINI, IVANO, FRAGAI, MARCO, LUCHINAT, CLAUDIO, MELIKIAN, MAXIME THIERRY OLIVIER, E. Mylonas, SARTI, NIKO, D. Svergun   +6 more
openaire   +3 more sources

Prognostic value of determination of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 in follicular fluid in patients in vitro fertilization programs [PDF]

Гинекология, 2021
Aim. To determine the prognostic significance of matrix metalloproteinase-1 (MMP-1) and tissue metalloproteinase-1 inhibitor (TIMP-1) in the follicular fluid (FF) in patients with infertility to improve the effectiveness of in vitro fertilization (IVF ...
Olga A. Marinova, Larisa I. Trubnikova, Marina L. Albutova   +2 more
doaj   +1 more source

Early loss of blood-brain barrier integrity precedes NOX2 elevation in the prefrontal cortex of an animal model of psychosis [PDF]

, 2016
The social isolation rearing of young adult rats is a model of psychosocial stress and provides a nonpharmacological tool to study alterations reminiscent of symptoms seen in psychosis.
Bove, Maria, Cuomo, Vincenzo, Di Giovanni, Giuseppe, Mhillaj, Emanuela, Morgese, Maria Grazia, Neri, Margherita, Pomara, Cristoforo, Schiavone, Stefania, Trabace, Luigia, Tucci, Paolo, Turillazzi, Emanuela, Valentino, Mario   +11 more
core   +4 more sources