Results 101 to 110 of about 19,208 (245)

Molecular and functional basis of phenotypic convergence in white lizards at White Sands [PDF]

, 2014
There are many striking examples of phenotypic convergence in nature, in some cases associated with changes in the same genes. But even mutations in the same gene may have different biochemical properties and thus different evolutionary consequences ...
Hoekstra, Hopi E., Rompler, H., Rosenblum, E. B., Schoneberg, T.   +3 more
core   +1 more source

Pigments, Chromatophore Structure, and Gene Expression Underlying Colour Polytypy of a Panamanian Poison Frog

Molecular Ecology, Volume 35, Issue 1, January 2026.
ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki, Giselle Tamayo‐Castillo, Víctor Vásquez‐Cháves, Abel Mora‐Machado, William J. Zamora Ramirez, Roberto Ibáñez, Heike Pröhl, Ariel Rodríguez   +7 more
wiley   +1 more source

Frontiers in Pigment Cell and Melanoma Research

, 2018
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca, Bosenberg, Marcus W., Box, Neil F., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Filipp, Fabian V., Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Poole, Caroline Le, Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S.   +26 more
core   +1 more source

Histologic and phenotypic factors and MC1R status associated with BRAF(V600E), BRAF(V600K), and NRAS mutations in a community-based sample of 414 cutaneous melanomas [PDF]

, 2016
Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes.
Green, Adele C., Hacker, Elke, Hayward, Nicholas K., Kvaskoff, Marina, Mortimore, Rohan, Olsen, Catherine M., Pandeya, Nirmala, Triscott, Joe, Whiteman, David C., Williamson, Richard M., Wood, Dominic, Yeo, Abrey   +11 more
core   +2 more sources

Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling.

Clinical science, 2020
The clinical effectiveness of adrenocorticotropin in inducing remission of steroid-resistant nephrotic syndrome points to a steroidogenic-independent anti-proteinuric activity of melanocortins.
Y. Qiao, Pei Wang, Mingyang Chang, Bohan Chen, Y. Ge, Deepak Malhotra, L. Dworkin, R. Gong   +7 more
semanticscholar   +1 more source

A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties

Skin Research and Technology, Volume 32, Issue 1, January 2026.
ABSTRACT Background With increasing life expectancy, the aging population, particularly in Asia, is expanding rapidly. Combined with intense year‐round ultraviolet exposure, this accelerates skin aging. Male skin also exhibits distinct aging characteristics.
Mingkwan Na Takuathung, Kantirat Yaja, Jakkrit Aisara, Preeyaporn Klinjan, Pannita Anek, Ratchanon Inpan, Tattiya Kantasa, Jeeraporn Chitphan, Kankanit Yeerong, Supanimit Teekachunhatean, Nut Koonrungsesomboon   +10 more
wiley   +1 more source

Functional variation of MC1R alleles from red-haired individuals [PDF]

Human Molecular Genetics, 2001
Red hair in humans is associated with variant alleles of the alphaMSH receptor gene, MC1R. Loss of MC1R function in other mammals results in red or yellow hair pigmentation. We show that a mouse bacterial artificial chromosome (BAC) which contains Mc1r will efficiently rescue loss of Mc1r in transgenic mice, and that overexpression of the receptor ...
Healy, Eugene, Jordan, Siobhán A., Budd, Peter S., Suffolk, Ruth, Rees, Jonathan L., Jackson, Ian J.   +5 more
openaire   +3 more sources

A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk. [PDF]

, 2017
Despite the recent identification of some novel risk genes for Alzheimer's disease (AD), the genetic etiology of late-onset Alzheimer's disease (LOAD) remains largely unknown.
Alcolea, Daniel, Antonell, Anna, Badenas Orquin, Celia, Clarimón, Jordi, Fernandez-Santiago, Rubén, Fortea Ormaechea, Juan, Lladó Plarrumaní, Albert, Lleó Bisa, Alberto, Molinuevo, José Luis, Plana, Estel, Potrony Mateu, Míriam, Puig Butillé, Joan Anton, Puig i Sardà, Susana, Sánchez del Valle Díaz, Raquel, Tell Martí, Gemma   +14 more
core   +1 more source

A Diagnosis of Dysplastic Naevus has no Clinical Relevance and Unnecessarily Confounds Therapeutic Decision‐Making

JEADV Clinical Practice, Volume 4, Issue 5, Page 969-981, December 2025.
ABSTRACT The term ‘dysplastic naevus’ first introduced in 1980, has since engendered considerable debate regarding its ontological legitimacy, the appropriateness of its nomenclature, and its potential prognostic significance. In this review, we undertake a critical examination of the extant literature, including a focus on the past decade.
Cliff Rosendahl, Simon Clark, Syril Keena T. Que, Denis Moir, Harald Kittler, Jane M. Grant‐Kels   +5 more
wiley   +1 more source

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: Study design and methods for pooling results of genetic epidemiological studies [PDF]

, 2012
Background: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease.
Cornelius, Lynn, et al,
core   +9 more sources