Results 81 to 90 of about 19,208 (245)

A novel spectral method for inferring general diploid selection from time series genetic data

, 2014
The increased availability of time series genetic variation data from experimental evolution studies and ancient DNA samples has created new opportunities to identify genomic regions under selective pressure and to estimate their associated fitness ...
Bhaskar, Anand, Song, Yun S., Steinrücken, Matthias   +2 more
core   +1 more source

Análisis de la asociación entre sexo y diferencias en pigmentación humana según el genotipo del gen MC1R [PDF]

, 2016
Introducción: La pigmentación cutánea basal y la respuesta al sol por bronceamiento son rasgos hereditarios influidos por varios genes, entre los que el gen mc1r es uno de los más importantes.
Hernando, Barbara, Ibarrola-Villava, Maider, Llorca-Cardeñosa, Marta J., Martinez-Cadenas, Conrado, Ribas, Gloria   +4 more
core   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, EarlyView.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Nuclear gene indicates coat-color polymorphism in mammoths [PDF]

, 2006
By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species.
Bertranpetit, Jaume, Hofreiter, Michael, Kuznetsova, Tatyana, Lalueza-Fox, Carles, Rabeder, Gernot, Rohland, Nadin, Römpler, Holger, Schöneberg, Torsten, Willerslev, Eske   +8 more
core   +1 more source

Genomic mapping identifies two genetic variants in the MC1R gene for coat colour variation in Chinese Tan sheep

PLoS ONE, 2020
Coat colour is one of the most important economic traits of sheep and is mainly used for breed identification and characterization. This trait is determined by the biochemical function, availability and distribution of phaeomelanin and eumelanin pigments.
G. Gebreselassie, Benmeng Liang, H. Berihulay, R. Islam, Adam Abied, Lin Jiang, Zhengwei Zhao, Yuehui Ma   +7 more
semanticscholar   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

MODELLING OF 3D-STRUCTURES OF THE RARE MELANOCORTIN-1-RECEPTOR MUTATIONS ASSOCIATED TO MELANISM IN THE BANANAQUIT

Acta Biológica Colombiana, 2020
Melanism in plumage color is often associated to the single nucleotide polymorphism of the melanocortin-1-receptor (MC1R). Despite the striking association between the substitution of a Glutamic-acid by for a Lysine at position 92 on the MC1R protein and
Raúl Ernesto Sedano-Cruz, Daniel Camilo Osorio   +1 more
doaj   +1 more source

Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in South Europeans [PDF]

, 2013
In humans, the geographical apportionment of the coding diversity of the pigmentary locus melanocortin-1 receptor (MC1R) is, unusually, higher in Eurasians than in Africans.
Alonso, Santos, Boyano, Dolores, de la Rúa, Concepción, Flores, Carlos, García de Galdeano, Alicia, García, Oscar, Gardeazabal, Jesús, Ibarrola-Villava, Maider, Izagirre, Neskuts, López, Saioa, Martinez-Cadenas, Conrado, Pino-Yanes, M ., Ribas, Gloria, Sevilla, Arrate, Smith-Zubiaga, I.   +14 more
core   +2 more sources

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, EarlyView.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source

Rare Germline Variants in CDKN2A‐Negative Children and Adolescents With Cutaneous Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 2, March 2026.
Individuals with childhood and adolescent melanoma carry inherited mutations in shelterin complex genes, pigmentation genes and MBD4, but have fewer MC1R R‐alleles than adults with melanoma. Created with BioRender.com. ABSTRACT Cutaneous melanoma is a complex disease influenced by both environmental and genetic factors. Inherited susceptibility plays a
Peter A. Johansson, Jane M. Palmer, Linh T. Bui‐Raborn, Mai Xu, Kristine M. Jones, Herbert Higson, Jia Liu, Kelly M. Brooks, Antonia L. Pritchard, Nicholas K. Hayward, Kevin M. Brown   +10 more
wiley   +1 more source