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MDSCs, ageing and inflammageing
Cellular Immunology, 2021The challenge of distinguishing between changes attributable to ageing and those attributable to pathology is even greater for the immune system than for many other organs, and this is especially true for myeloid-derived suppressor cells (MDSCs). Hematopoiesis is different in older adults with a bias towards myelopoiesis, and older adults also manifest
Graham, Pawelec +4 more
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Switching off MDSCs by targeting REL [PDF]
Nature Reviews Cancer, 2020 Ting Li, Xinyuan Li et al. determined that REL, a member of the nuclear factor-κB (NF-κB) family of transcription factors, has a key role in generating myeloid-derived suppressor cells (MDSCs) and that targeting REL might be used for cancer immunotherapy.
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Targeting YTHDF2/MDSCs to improve radiotherapy
Cell Chemical Biology, 2023Immunosuppression contributes to tumor-radiotherapy failure, but the mechanism remains elusive. Wang et al.1 reported that ionizing radiation (IR) induces YTHDF2 expression in myeloid-derived suppressor cells (MDSCs) via an IR-YTHDF2-NF-κB circuit, which contributes to MDSC expansion/migration and treatment failure. Genetic depletion or pharmacological
Xiaolan, Deng, Ying, Qing, Jianjun, Chen
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MDSCs sneak CSCs out of (immuno)surveillance
Trends in Immunology, 2022Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of ...
Carlos Jiménez-Cortegana +2 more
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Nature Reviews Immunology, 2020
A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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MDSC: Markers, development, states, and unaddressed complexity
Immunity, 2021Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities in immunology. While the context and classification of this group of cells has evolved, MDSCs most commonly describe cells arising during chronic inflammation, especially late-stage cancers, and are defined by their T cell immunosuppressive functions.
Samarth, Hegde +2 more
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