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Monocytic MDSCs regulate macrophage-mediated xenogenic cytotoxicity
Transplant Immunology, 2015Xenotransplantation is considered to be one of the most attractive strategies for overcoming the worldwide shortage of organs. However, many obstructions need to be overcome before it will achieve clinical use in patients. One such obstacle is the development of an effective immunosuppressive strategy.
Akira, Maeda +10 more
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Tumor-related stress regulates functional plasticity of MDSCs
Cellular Immunology, 2021Myeloid-derived suppressor cells (MDSCs) impair protective anti-tumor immunity and remain major obstacles that stymie the effectiveness of promising cancer therapies. Diverse tumor-derived stressors galvanize the differentiation, intra-tumoral expansion, and immunomodulatory function of MDSCs.
Jessica K. Mandula, Paulo C. Rodriguez
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Phenotypic Plasticity of MDSC in Cancers
Immunological Investigations, 2012Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth.
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Science, 2020
Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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Tumor Immunology Myeloid-derived suppressor cells (MDSCs) are immune cells that mediate immune suppression and are correlated with progressing cancer. How these cells arise and whether they can be therapeutically targeted akin to exhausted T cells are areas of active investigation. A persistent challenge in studying MDSCs has been the identification of
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Abstract 755: Antagonistic effect of M-MDSC and N-MDSC during astrocytoma progression
Cancer Research, 2016Abstract The traditional dogma holds that tumor size has a positive correlation with tumor progression. However, on murine orthotopical astrocytoma model ALTS1C1, we found that the tumor growth is not a linear function instead a shrinkage and regrowth wave was noticed.
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Mission Data Storage Consolidation (MDSC)
SpaceOps 2002 Conference, 2002This paper describes a storage related project undertaken on the Consolidated Space Operations Contract (CSOC) by Lockheed Martin Space Operations (LMSO). The project, Mission Data Storage Consolidation (MDSC), was defined with the intent of enabling NASA’s Johnson Space Center (JSC) to reduce storage costs in ground systems and related support ...
Ray Hunnicutt, David Garza
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Ex Vivo MDSC Differentiation Models
2016The development of adequate ex vivo cell differentiation models is the key for the study of cell ontology and functions. For example, since ex vivo differentiation systems for conventional myeloid dendritic cells (DCs) were developed, research in these important regulators of immunity was significantly increased.
David Escors, Grazyna Kochan
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Rapid Isolation of untouched mouse MDSCs
The Journal of Immunology, 2019Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that regulate immune responses in cancer, chronic infections and inflammatory conditions. In an individual with a tumor burden, MDSCs accumulate in peripheral lymphoid organs and within the tumor microenvironment.
Frann Antignano +7 more
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Pak2 Regulates MDSC Development and Function
Blood, 2016Abstract Myeloid derived suppressor cells (MDSCs) are a heterogeneous cell population at various stages of differentiation that can increase under various pathologic conditions such as cancer, infection or inflammation, displaying suppressive function.
Yi Zeng +5 more
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