Results 61 to 70 of about 167,726,296 (242)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Datification and the pursuit of meaningfulness in work [PDF]

, 2019
Proliferation of digital means of tracking worker activities has contributed to the rise of data-driven approaches to managing people, with employees often required to record their activities for accountability purposes.
Pamela Tierney, Robert D. Galliers, Tierney, Pamela, Wagner, Erica L., Sue Newell, Mari‐Klara Stein, Newell, Susan, Stein, Mari-Klara, Newell, Sue, Galliers, Robert D., Erica L. Wagner   +10 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Unraveling key drivers for engineer creativity and meaningfulness of work: Bayesian network approach [PDF]

, 2020
This study builds on an existing structural model developed to examine the influence of leadership and organizational culture on innovation and satisfaction of engineers in Australian public sectors (APS).
Panuwatwanich, Kriengsak, Sunkpho, Jirapon, Stewart, Rodney A., Stewart, Rodney A, Parnphumeesup, Piya, Wipulanusat, Warit   +5 more
core   +1 more source

Assessing the Impact of COVID-19 on Social Work Students: Burnout and Resilience During a Global Pandemic

, 2023
COVID-19 had a profound impact on teaching and learning at academic institutions across the globe. This study examined the experiences of social work students (n = 884) during the pandemic and their associated level of burnout.
White, Kurt, Keesler, John M., Wilkerson, David, Dickinson, Stephanie   +3 more
core   +1 more source

Employee engagement: The effects of work-home/home-work interaction and psychological conditions

South African Journal of Economic and Management Sciences, 2014
The aim of this study was to investigate the relationship between work-home and home-work interference, psychological conditions and employee engagement. A cross-sectional survey design was used.
Sebastiaan Rothmann, Candice Baumann
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

‘Killing Me Softly With His/Her Song’: How Leaders Dismantle Followers’ Sense of Work Meaningfulness

Frontiers in Psychology, 2018
Leaders influence followers’ meaning and play a key role in shaping their employees’ experience of work meaningfulness. While the dominant perspective in theory and in empirical work focuses on the positive influence of leaders on followers’ work ...
Petra Kipfelsberger, Ronit Kark
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The interplay of job embeddedness, collective efficacy, and work meaningfulness on teacher well-being: a mixed-methods study with digital ethnography in China

Frontiers in Psychology
IntroductionThis study examines the influence of teacher job embeddedness, collective efficacy, and work meaningfulness on the psychological well-being of Chinese teachers.
Yumei Lei
doaj   +1 more source