Mechanotransduction, cellular - Open Access .click

Annals of Biomedical Engineering, 2005
Mechanotransduction, the transformation of an applied mechanical force into a cellular biomolecular response, is briefly reviewed focusing on fluid shear stress and endothelial cells. Particular emphasis is placed on recent studies of the surface proteoglycan layer (glycocalyx) as a primary sensor of fluid shear stress that can transmit force to apical
John M, Tarbell, Sheldon, Weinbaum, Roger D, Kamm +2 more
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Cellular mechanisms involved in mechanotransduction

Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), 2003
Fluid flow induces increased c-fos and COX-2 expression in MC3T3-E1 cells that is dependent on flow-induced actin stress fiber formation(ASFF). The roles of intracellular Ca/sup 2+/ ([Ca/sup 2+/]) and Ca/sup 2+/ channels in these responses were examined using agents that alter [Ca/sup 2+/]/sub i/, release and Ca/sup 2+/ entry.
R. Duncan +5 more
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Cellular Basis of Mechanotransduction

The Biological Bulletin, 1998
Physical forces, such as those due to gravity are fundamental regulators of tissue development. To influence morphogenesis, mechanical forces must alter growth and function. Yet little is known about how cells convert mechanical signals into a chemical response.
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mechanotransduction
mechanobiology
cytoskeleton

focal adhesion
mechanosensing
linc complex

extracellular matrix
medicine
biotechnology