Results 71 to 80 of about 22,933 (258)

3D Printing Strategies for Bioengineering Human Cornea

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in 3D bioprinting strategies for engineering human corneas. Key aspects include the replication of corneal transparency, curvature, and biomechanical properties, alongside innovations in recent advancements in 3D printing methods, which benefit in overcoming current challenges.
Yunong Yuan, Khoon S. Lim, Gerard Sutton, Gordon G. Wallace, Jingjing You   +4 more
wiley   +1 more source

Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments [PDF]

Advanced Healthcare Materials, 2017
Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells. This progress report provides a critical overview of key studies that incorporate growth factor (GF) signalling and mechanotransduction into the design of advanced microenvironments.
Cipitria, Amaia, Salmeron-Sanchez, Manuel   +1 more
openaire   +4 more sources

Upregulation of matrix synthesis in chondrocyte-seeded agarose following sustained bi-axial cyclic loading

Clinics, 2012
OBJECTIVES: The promotion of extracellular matrix synthesis by chondrocytes is a requisite part of an effective cartilage tissue engineering strategy.
Belinda Pingguan-Murphy, Illida Nawi
doaj   +1 more source

Hydrogels with Tunable Physical Cues and Their Emerging Roles in Studies of Cellular Mechanotransduction

Advanced NanoBiomed Research, 2021
The extracellular matrix provides complex biophysical cues to cells which respond to these signals with signaling cascades that determine various cellular processes including fate.
Badri Narayanan Narasimhan, Matthew S. Horrocks, Jenny Malmström   +2 more
doaj   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

Cofilin-1 Is a Mechanosensitive Regulator of Transcription

Frontiers in Cell and Developmental Biology, 2020
The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment’s stiffness.
Catarina Domingues, Catarina Domingues, A. Margarida Geraldo, Sandra Isabel Anjo, André Matos, André Matos, Cláudio Almeida, Cláudio Almeida, Inês Caramelo, Inês Caramelo, José A. Lopes-da-Silva, Artur Paiva, Artur Paiva, Artur Paiva, Artur Paiva, João Carvalho, Ricardo Pires das Neves, Ricardo Pires das Neves, Bruno Manadas, Mário Grãos, Mário Grãos, Mário Grãos   +21 more
doaj   +1 more source

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Sensing the squeeze: nuclear mechanotransduction in health and disease

Nucleus
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical ...
Luv Kishore Srivastava, Allen J. Ehrlicher   +1 more
doaj   +1 more source