Results 181 to 190 of about 16,738 (225)
microRNAs in the Regulation of Melanogenesis [PDF]
International Journal of Molecular Sciences, 2021 Melanogenesis is the process leading to the synthesis of melanin, the main substance that influences skin color and plays a pivotal role against UV damage. Altered melanogenesis is observed in several pigmentation disorders. Melanogenesis occurs in specialized cells called melanocytes, physically and functionally related by means of autocrine and ...
Lucia Oton-Gonzalez +2 more
exaly +6 more sources
Signaling Pathways in Melanogenesis [PDF]
International Journal of Molecular Sciences, 2016 Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes.
Graeme Finlay +2 more
exaly +5 more sources
Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
Materials, 2012 Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported ...
Te-Sheng Chang, Chang Te-Sheng
exaly +2 more sources
Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan
International Journal of Molecular Sciences, 2012 Homoisoflavanone, sappanone A, was isolated from Caesalpinia sappan and proven to dose-dependently inhibit both melanogenesis and cellular tyrosinase activity via repressing tyrosinase gene expression in mouse B16 melanoma cells.
Te-Sheng Chang +2 more
exaly +2 more sources
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Boolean model for melanogenesis
Physical Biology, 2021Abstract Melanogenesis is a highly regulated process through which the pigment melanin is produced in skin cells. Irregularities in the molecular events that govern the process of skin pigmentation can cause disorders like vitiligo. In order to understand the biology of disease progression, it is important to have
Pooja Dnyane, Chetan Gadgil
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Epigenetic regulation of melanogenesis
Ageing Research Reviews, 2021Melanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides.
Shihang Zhou +12 more
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Pigment Cell Research, 2003
Melanins are the principal surface pigments in vertebrates and, in humans, play a major role in photoprotection. Although the product (melanin) has a mainly protective function in the skin, the process of melanogenesis represents a potential cellular hazard and is confined to special membrane‐limited organelles (melanosomes) in a set of specialized ...
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Melanins are the principal surface pigments in vertebrates and, in humans, play a major role in photoprotection. Although the product (melanin) has a mainly protective function in the skin, the process of melanogenesis represents a potential cellular hazard and is confined to special membrane‐limited organelles (melanosomes) in a set of specialized ...
openaire +2 more sources
Melanogenesis and Skin Carcinoma
Archives of Dermatology, 1960It has long been alleged that the ultraviolet portion of sunlight contributes etiologically to the development of carcinoma of the skin. However, the exact mechanism of action whereby and the degree to which ultraviolet influences carcinogenesis have never been clarified in humans.
M A, EVERETT, R, BELL, J A, HAGANS
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Melanogenesis in human melanomas
Plastic and Reconstructive Surgery, 1975A number of biochemical aspects of melanogenesis were studied in 15 variously melanized human melanomas. The tryosinase activity was correlated with the degree of melanoma varied from 3,667 to 46,183 tryosinase units, in partially melanotic melanoma it varied from 14 to 75 tryrosinase units.
Y M, Chen, W, Chavin
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Trace metals and melanogenesis
Experientia, 1983Emission spectroscopic analysis of amphibian and mammalian skin ash for the study of trace metals shows that nickel, lead and tin may play some role in the pigmentation-depigmentation process.
D P, Chakraborty +3 more
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