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microRNAs in the Regulation of Melanogenesis [PDF]
International Journal of Molecular Sciences, 2021 Melanogenesis is the process leading to the synthesis of melanin, the main substance that influences skin color and plays a pivotal role against UV damage. Altered melanogenesis is observed in several pigmentation disorders. Melanogenesis occurs in specialized cells called melanocytes, physically and functionally related by means of autocrine and ...
Giulia di Mauro +2 more
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Signaling Pathways in Melanogenesis [PDF]
International Journal of Molecular Sciences, 2016 Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes.
Graeme Finlay +2 more
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Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
Materials, 2012 Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported ...
Te-Sheng Chang
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Rottlerin Reduces cAMP/CREB-Mediated Melanogenesis via Regulation of Autophagy
International Journal of Molecular Sciences, 2019 Melanogenesis is the sequential process of melanin production by melanocytes in order to protect the skin from harmful stimuli. Melanogenesis is disrupted by radiation exposure, which results in the differentiation of melanocytes into melanoma. Recently,
Mi-Yeon Kim +2 more
exaly +2 more sources
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Boolean model for melanogenesis
Physical Biology, 2021Abstract Melanogenesis is a highly regulated process through which the pigment melanin is produced in skin cells. Irregularities in the molecular events that govern the process of skin pigmentation can cause disorders like vitiligo. In order to understand the biology of disease progression, it is important to have
Pooja Dnyane, Chetan Gadgil
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Epigenetic regulation of melanogenesis
Ageing Research Reviews, 2021Melanogenesis is a complex process in which melanin is synthesized in melanocytes and transported to keratinocytes, which involves multiple genes and signaling pathways. Epigenetics refers to the potential genetic changes that affect gene expression without involving changes in the original sequence of DNA nucleotides.
Shihang Zhou +12 more
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Frontiers in Molecular BiosciencesMelanin is an amino acid derivative produced by melanocyte through a series of enzymatic reactions using tyrosinase as substrate. Human skin and hair color is also closely related to melanin, so understanding the mechanisms and proteins that produce melanin is very important.
Xiaohong An
exaly +4 more sources