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The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins

Frontiers in Molecular Biosciences
Melanin is an amino acid derivative produced by melanocyte through a series of enzymatic reactions using tyrosinase as substrate. Human skin and hair color is also closely related to melanin, so understanding the mechanisms and proteins that produce melanin is very important.
Xiaohong An
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Melanogenesis and Melanoma

Pigment Cell Research, 2003
Melanins are the principal surface pigments in vertebrates and, in humans, play a major role in photoprotection. Although the product (melanin) has a mainly protective function in the skin, the process of melanogenesis represents a potential cellular hazard and is confined to special membrane‐limited organelles (melanosomes) in a set of specialized ...
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Melanogenesis in human melanomas

Plastic and Reconstructive Surgery, 1975
A number of biochemical aspects of melanogenesis were studied in 15 variously melanized human melanomas. The tryosinase activity was correlated with the degree of melanoma varied from 3,667 to 46,183 tryosinase units, in partially melanotic melanoma it varied from 14 to 75 tryrosinase units.
Y M, Chen, W, Chavin
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Melanogenesis and Skin Carcinoma

Archives of Dermatology, 1960
It has long been alleged that the ultraviolet portion of sunlight contributes etiologically to the development of carcinoma of the skin. However, the exact mechanism of action whereby and the degree to which ultraviolet influences carcinogenesis have never been clarified in humans.
M A, EVERETT, R, BELL, J A, HAGANS
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Trace metals and melanogenesis

Experientia, 1983
Emission spectroscopic analysis of amphibian and mammalian skin ash for the study of trace metals shows that nickel, lead and tin may play some role in the pigmentation-depigmentation process.
D P, Chakraborty, C, Chakraborty, M, Ganguly, A K, Chakraborty   +3 more
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Ascorbic acid and melanogenesis

British Journal of Dermatology, 1977
The ascorbic acid contents of skin, plasma and urine were estimated in 12 vitiligo cases, one albino and 10 normal subjects. All the estimations were repeated after saturation with ascorbic acid. There was no difference between the two groups with regard to the ascorbic acid contents of their plasma or urine.
A V, Ratnam, P B, Sastry, B V, Satyanarayana   +2 more
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Melanogenesis in frog skin

Experientia, 1968
Es wurden die anatomische und subzellulare Verteilung der Tyrosinaseaktivitat im Integument und die Tyrosincarboxylinkorporation in Melanin beiRana pipiens undRana catesbiana festgestellt und gefunden, dass die Tyrosinaseaktivitat in der Bauchhaut hoher ist als in der Ruckenhaut, wahrend die Seitenhaut dazwischenliegende Werte liefert.
Y M, Chen, W, Chavin
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Quinone Chemistry and Melanogenesis

2004
Publisher Summary The divergence of the melanogenic pathway occurs after the initial oxidation step that yields dopaquinone. The current analytical approach to the classification of melanins depends on the assessment of the comparative levels of degradation products that are considered characteristic of indoles and benzothiazine residues.
Edward J, Land, Christopher A, Ramsden, Patrick A, Riley   +2 more
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Melanin, Melanogenesis, and Vitiligo

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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The structure of melanins and melanogenesis—III

Tetrahedron, 1962
Abstract A comparative study on sepiomelanin and three synthetic pigments, namely dopa melanin, 5,6-dihydroxyindole melanin and pyrrole black, has been carried out. Sepiomelanin is structurally related to 5,6-dihydroxyindole and dopa melanins. The only observed differences are the absence of carboxyl groups in position 2 of the indole nuclei in the ...
M. Piattelli, E. Fattorusso, R.A. Nicolaus, S. Magno   +3 more
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