Results 31 to 40 of about 177,226 (339)

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources

Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. [PDF]

, 2020
BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain.
Catoiu, Edward, Fang, Xin, Heckmann, David, Mih, Nathan, Monk, Jonathan M, Palsson, Bernhard O, Yang, Laurence   +6 more
core   +2 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
AG Barbour, AG Barbour, AG Barbour, AG Barbour, AS Coleman, C Neeleman, C Siegel, C Skerka, CA Brissette, Christiane Brenner, CS Brooks, D Raoult, David M. Ojcius, DJ Grab, E Rossmann, E Rossmann, GD Wieland, H Fuchs, J Bunikis, JA Gebbia, JC Scott, JC Setubal, JL Coleman, JV McDowell, K Hartmann, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, Markus M. Simon, MD Kramer, Melanie Schott, MK Pangburn, NM Ras, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Kraiczy, P Stewart, Peter F. Zipfel, Peter Kraiczy, PF Zipfel, PF Zipfel, PM Southern, RD Horstmann, Reinhard Wallich, S Hammerschmidt, S Kuhn, S Kuhn, S Poltermann, S Ram, Sally J. Cutler, SH Rooijakkers, SJ Cutler, Sonja Grosskinsky, T Meri, T Meri, WR Zuckert   +59 more
core   +9 more sources

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

eLife, 2016
Lamin B receptor (LBR) is a polytopic membrane protein residing in the inner nuclear membrane in association with the nuclear lamina. We demonstrate that human LBR is essential for cholesterol synthesis.
Pei-Ling Tsai, Chenguang Zhao, Elizabeth Turner, Christian Schlieker   +3 more
doaj   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Expression of membrane cofactor protein (MCP, CD46) in human liver diseases [PDF]

British Journal of Cancer, 1999
Membrane cofactor protein (MCP, CD46) is one of the complement regulatory proteins, and is widely distributed in human organs and protects cells from complement-mediated cytotoxicity. We analysed the distribution and the intensities of MCP in liver diseases and evaluated the role of MCP during hepatocarcinogenesis.
Kinugasa, N, Higashi, T, Nouso, K, Nakatsukasa, H, Kobayashi, Y, Ishizaki, M, Toshikuni, N, Yoshida, K, Uematsu, S, Tsuji, T   +9 more
openaire   +2 more sources

Development of α 1,3-galactosyltransferase Inactivated and Human Membrane Cofactor Protein Expressing Homozygous Transgenic Pigs for Xenotransplantation

Journal of Animal Reproduction and Biotechnology, 2017
Transplantation is considered to be a very useful approach to improve human welfare and to prolong life-span. Heterologous organ transplantation using pig organs which are similar to human beings and easy to make mass-production has known as one of the ...
Gunsup Lee, Sang Hyoun Park, Haesun Lee, Soo-Jeong Ji, Joo Yung Lee, Sung-June Byun, Seongsoo Hwang, Kyung Woon Kim, Sun A Ock, Keon Bong Oh   +9 more
doaj   +1 more source

Conformational and mechanical stability of the isolated large subunit of membrane-bound [NiFe]-hydrogenase from Cupriavidus necator

Frontiers in Microbiology, 2023
Comprising at least a bipartite architecture, the large subunit of [NiFe]-hydrogenase harbors the catalytic nickel–iron site while the small subunit houses an array of electron-transferring Fe-S clusters.
Jovan Dragelj, Chara Karafoulidi-Retsou, Sagie Katz, Oliver Lenz, Ingo Zebger, Giorgio Caserta, Sophie Sacquin-Mora, Sophie Sacquin-Mora, Sophie Sacquin-Mora, Maria Andrea Mroginski   +9 more
doaj   +1 more source

Molecular cloning of a pig homologue of membrane cofactor protein (CD46) [PDF]

International Immunology, 1997
Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement.
K, Toyomura, T, Fujimura, H, Murakami, T, Natsume, T, Shigehisa, N, Inoue, J, Takeda, T, Kinoshita   +7 more
openaire   +2 more sources

Network analysis reveals how lipids and other cofactors influence membrane protein allostery [PDF]

The Journal of Chemical Physics, 2020
Many membrane proteins are modulated by external stimuli, such as small molecule binding or change in pH, transmembrane voltage, or temperature. This modulation typically occurs at sites that are structurally distant from the functional site. Revealing the communication, known as allostery, between these two sites is key to understanding the ...
Annie M. Westerlund, Oliver Fleetwood, Sergio Pérez-Conesa, Lucie Delemotte   +3 more
openaire   +5 more sources