The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
Neural Regeneration Research, 2023 Recent studies have proposed three lymphatic drainage systems in the brain, that is, the glymphatic system, the intramural periarterial drainage pathway, and meningeal lymphatic vessels, whose roles in various neurological diseases have been widely ...
Ying-Jie Wang +6 more
doaj +1 more source
Technical Developments and Ex Vivo Demonstration in a Mouse Model of Neuroinflammation [PDF]
, 2017 Neuroinflammation can be monitored using fluorine-19 (19F)-containing nanoparticles and 19F MRI. Previously we studied neuroinflammation in experimental autoimmune encephalomyelitis (EAE) using room temperature (RT) 19F radiofrequency (RF) coils and low ...
Boehm-Sturm, Philipp [u.a.] +7 more
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Anatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation [PDF]
, 2020 Respiratory infections can result in intracranial infections and unknown neurological symptoms. The central nervous system lacks classical meningeal lymphatic (circulation) drainage, and the exact underlying mechanisms of how immune cells from the ...
Chen, Tao +5 more
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Brain and Behavior, 2023 Background The discovery of the glymphatic system and meningeal lymphatic vessels challenged the traditional view regarding the lack of a lymphatic system in the central nervous system.
Yuheng Liu +9 more
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Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
, 2018 Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim +9 more
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Stroke: Vascular and Interventional Neurology, 2021 Introduction: Until recently, there was very little known about the brain’s waste removal system. Unlike the peripheral organ systems, the CNS lacked a clearly defined lymphatic vasculature and waste clearance mechanism.
Richard Pham, Rano Chatterjee
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Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury
Brain, Behavior, & Immunity - Health, 2022 Understanding the pathological mechanisms unfolding after chronic traumatic brain injury (TBI) could reveal new therapeutic entry points. During the post-TBI sequel, the involvement of cerebrospinal fluid drainage through the meningeal lymphatic vessels ...
Anaïs Virenque +11 more
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Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases
Frontiers in Cellular Neuroscience, 2021 The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu +3 more
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Brain interference: Revisiting the role of IFNγ in the central nervous system [PDF]
, 2017 Interferon gamma (IFN-gamma) is a pro-inflammatory cytokine, first described as a secreted molecule capable of interfering with viral replication. Since then, numerous other important actions in the context of the immune response to invading pathogens ...
Cerqueira, João José +4 more
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Chronic lymphocytic leukemia and the central nervous system: a clinical and pathological study. [PDF]
, 1996 Chronic lymphocytic leukemia is the most common human leukemia but infrequently causes neurologic symptoms. We have reviewed all previously reported cases of chronic lymphocytic leukemia in the CNS along with three new cases; one patient was diagnosed ...
Cramer, SC +3 more
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