Results 51 to 60 of about 6,015 (163)

마우스 모델에서 [64Cu]Cu-Albumin 분자영상을 활용한 뇌척수액의 림프 유출 규명 [PDF]

, 2022
학위논문(박사) -- 서울대학교대학원 : 의과대학 의학과, 2022. 8. 이동수.서론: 뇌척수액 림프 유출의 기능 장애와 그로 인한 뇌 노폐물 제거 감소는 노화 과정 및 신경 퇴행성 질환의 원인이 되는 것으로 밝혀지고 있음. 뇌척수액 림프 유출 기능 평가는 주로 형광 영상과 자기 공명 영상(MRI)에 의존했지만 이러한 방식은 생리 변화를 최소화하고 임상적용에 있어 제한이 있음.
아즈말
core  

The glymphatic system and its role in cerebral homeostasis [PDF]

, 2020
The brain’s high bioenergetic state is paralleled by high metabolic waste production. Authentic lymphatic vasculature is lacking in brain parenchyma. Cerebrospinal fluid (CSF) flow has long been thought to facilitate central nervous system detoxification
Benveniste, Helene, Elkin, Rena, Heerdt, Paul, Koundal, Sunil, Lee, Hedok, Tannenbaum, Allen, Wardlaw, Joanna, Xue, Yuechuan   +7 more
core   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases [PDF]

, 2021
The field of neuroimmunology endorses the involvement of the adaptive immune system in central nervous system (CNS) health, disease, and aging. While immune cell trafficking into the CNS is highly regulated, small numbers of antigen-experienced ...
Gericke, Christoph, Rickenbach, Chiara
core   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination [PDF]

The precise neurophysiological changes prompted by meningeal lymphatic dysfunction remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in ...
Almeida, Francisco, Barber, Megan J, Cucuzza, Chiara Starvaggi, Da Mesquita, Sandro, das Neves, Sofia P, Delivanoglou, Nickoleta, Faroqi, Ayman H, Irani, Sarosh R, Makuch, Mateusz, McLean, Pamela J, Oliveira, Tiago Gil, Piehl, Fredrik, Rego, Shanon, Ren, Yingxue, Sanchez, Guadalupe, Schrader, Racquelle, Thomas, Jean-Leon   +16 more
core   +2 more sources

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, Volume 97, Issue 6, Page 1074-1087, June 2025.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology [PDF]

, 2021
Aging leads to a progressive deterioration of meningeal lymphatics and peripheral immunity, which may accelerate cognitive decline. We hypothesized that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells ...
Baker, Wendy, Da Mesquita, Sandro, Dabhi, Nisha, de Lima, Kalil Alves, Dykstra, Taitea, Herz, Jasmin, Kennedy, Tatiana, Kipnis, Jonathan, Norris, Geoffrey T, Wall, Morgan   +9 more
core   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, Volume 6, Issue 5, May 2025.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
wiley   +1 more source

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, Volume 6, Issue 5, May 2025.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source