Results 51 to 60 of about 8,221 (187)

Remarkable preservation of brain tissues in an Early Cretaceous iguanodontian dinosaur [PDF]

, 2016
It has become accepted in recent years that the fossil record can preserve labile tissues. Here we report highly detailed mineralisation of soft tissues associated with a naturally occurring brain endocast of an iguanodontian dinosaur, found in ~133 Ma ...
Antcliffe, Jonathan, Brasier, Martin, Cotton, Laura J, Garwood, Russell, Hiscocks, Jamie, Liu, Alex, Norman, David, Wacey, David   +7 more
core   +7 more sources

Mapping meningeal vasculature in non-human primates

Veins and Lymphatics, 2022
Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson, Kyle Hauser, Scott Muller, Jeffrey H. Kordower, Liudmila Romanova   +4 more
doaj   +1 more source

Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity [PDF]

, 2017
No abstract ...
Habenicht, Andreas J.R., Maffia, Pasquale, Mohanta, Sarajo, Yin, Changjun   +3 more
core   +2 more sources

Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology [PDF]

Nature Cardiovascular Research
AbstractDiscovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their possible involvement in Alzheimer’s disease (AD). Here we find that in the APdE9 and 5xFAD mouse models of AD, dural amyloid-β (Aβ) is confined to blood ...
Salli Antila, Dmitri Chilov, Harri Nurmi, Zhilin Li, Anni Näsi, Maria Gotkiewicz, Valeriia Sitnikova, Henna Jäntti, Natalia Acosta‐Baena, Hennariikka Koivisto, J. Ray, Meike Hedwig Keuters, Ibrahim Sultan, Flavia Scoyni, Davide M Trevisan, Sara Wojciechowski, Mika Kaakinen, Lenka Dvořáková, Abhishek Singh, Jari Jukkola, Nea Korvenlaita, Lauri Eklund, Jari Koıstınaho, Sinem Karaman, Tarja Malm, Heikki Tanila, Kari Alitalo   +26 more
openalex   +4 more sources

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development [PDF]

, 2017
The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined zebrafish
Hawkins, TA, Rihel, J, Schulte-Merker, S, Shibata-Germanos, S, Van Impel, A, Van Lessen, M   +5 more
core   +1 more source

Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective

Neuroscience Insights, 2019
The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system.
Korri S Hershenhouse, Orr Shauly, Daniel J Gould, Ketan M Patel   +3 more
doaj   +1 more source

Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice

Journal of Clinical Investigation
Migraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used constitutive and inducible knockouts of the CGRP receptor components, elegantly demonstrating an essential function of CGRP in modulating meningeal lymphatic vessels (MLVs) in ...
Jean‐Léon Thomas, Emmanuelle A. D. Schindler, Christopher Gottschalk   +2 more
openalex   +3 more sources

Spontaneous activity in peripheral diaphragmatic lymphatic loops. [PDF]

, 2013
The spontaneous contractility of FITC-dextran-filled lymphatics at the periphery of the pleural diaphragm was documented for the first time “in vivo” in anesthetized Wistar rats. We found that lymphatic segments could be divided into four phenotypes: 1)
Marcozzi C, Moriondo A, Negrini D, Solari E   +3 more
core   +1 more source

The lymphatic drainage systems in the brain: a novel target for ischemic stroke?

Neural Regeneration Research, 2023
Recent studies have proposed three lymphatic drainage systems in the brain, that is, the glymphatic system, the intramural periarterial drainage pathway, and meningeal lymphatic vessels, whose roles in various neurological diseases have been widely ...
Ying-Jie Wang, Yan-Rong Sun, Yan-Hong Pei, Hao-Wen Ma, Ya-Kun Mu, Li-Hua Qin, Jun-Hao Yan   +6 more
doaj   +1 more source

rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

Brain and Behavior, 2023
Background The discovery of the glymphatic system and meningeal lymphatic vessels challenged the traditional view regarding the lack of a lymphatic system in the central nervous system.
Yuheng Liu, Xuanhui Liu, Pengju Sun, Jing Li, Meng Nie, Junjie Gong, Anqi He, Mingyu Zhao, Chen Yang, Zengguang Wang   +9 more
doaj   +1 more source