Results 61 to 70 of about 8,221 (187)

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Frontiers in Cellular Neuroscience, 2021
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu, Collin Laaker, Matyas Sandor, Zsuzsanna Fabry   +3 more
doaj   +1 more source

Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions [PDF]

, 2020
There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases.
Abdurashitov, Arkady, Agranovich, Ilana, Blokhina, Inna, Dubrovsky, Alexander, Klimova, Maria, Kurths, Jurgen, Kuznecova, Anna, Lezhnev, Nikita, Rafailov, Edik, Semyachkina-glushkovskaya, Oxana, Shirokov, Alexander, Shnitenkova, Anastassia, Terskov, Andrey, Tuchin, Valery, Vinnik, Valeria   +14 more
core   +2 more sources

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Brain, Behavior, & Immunity - Health, 2022
Understanding the pathological mechanisms unfolding after chronic traumatic brain injury (TBI) could reveal new therapeutic entry points. During the post-TBI sequel, the involvement of cerebrospinal fluid drainage through the meningeal lymphatic vessels ...
Anaïs Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Müller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe   +11 more
doaj   +1 more source

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery [PDF]

, 2018
The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D.
A Anisimov, A Louveau, AK Alitalo, G Paxinos, H Nurmi, K Alitalo, P Colella, S Antila, S Fang, S Karaman, TV Petrova   +10 more
core   +1 more source

Technical Developments and Ex Vivo Demonstration in a Mouse Model of Neuroinflammation [PDF]

, 2017
Neuroinflammation can be monitored using fluorine-19 (19F)-containing nanoparticles and 19F MRI. Previously we studied neuroinflammation in experimental autoimmune encephalomyelitis (EAE) using room temperature (RT) 19F radiofrequency (RF) coils and low ...
Boehm-Sturm, Philipp [u.a.], Delgado, Paula Ramos, Huelnhagen, Till, Koch, Stefan P., Millward, Jason M., Prinz, Christian, Starke, Ludger, Waiczies, Sonia   +7 more
core   +1 more source

Meningeal Lymphatic Vessel Flow Runs Countercurrent to Venous Flow in the Superior Sagittal Sinus of the Human Brain

Tomography, 2018
The recent report of the existence of meningeal lymphatic vessels (MLVs) in human and nonhuman primates used both histology and magnetic resonance imaging (MRI). Many questions about the physiology and function of these lymphatic vessels remain unanswered.
Phillip H. Kuo, Carol Stuehm, Scott Squire, Kevin M. Johnson   +3 more
openalex   +4 more sources

Central nervous system lymphatic unit, immunity, and epilepsy : Is there a link? [PDF]

, 2019
Summary The recent definition of a network of lymphatic vessels in the meninges surrounding the brain and the spinal cord has advanced our knowledge on the functional anatomy of fluid movement within the central nervous system (CNS).
Abbott, Abbott, Abbott, Absinta, Al Nimer, Ali, Alitalo, Amor, Andrian, Antila, Aspelund, Bar-Klein, Barker, Bauer, Bauer, Betterman, Bhowmik, Bien, Brinker, Brouillard, Carare, Carare, Cserr, Daneman, Decker, Engel, Engelhardt, Frigerio, Galea, Gendelman, Giannoni, Granata, Guo, Haraldsen, Harling-Berg, Hawkins, Hladky, Hladky, Huggenberger, Iliff, Irani, Jones, Kandratavicius, Karaman, Kataru, Kerchner, Kesler, Kida, Kim, Klement, Kuo, Lancaster, Lei, Li, Liang, Liu, Lonser, Louveau, Louveau, Louveau, Maggio, Makinen, Marchi, Marchi, Marchi, Marchi, Marchi, Mendes, Molteni, Monti, Omalu, Omalu, Pardo, Perry, Plog, Podgrabinska, Puvenna, Rasmussen, Roberson, Robitaille, Saletti, Sarnat, Scheffer, Schwab, Sen, Shirai, Shultz, Sotiropoulos, Stamatovic, Szentistvanyi, Szuba, Tammela, Thom, Thomas, Tomkins, Tomkins, Urra, Varadkar, Vazana, Vezzani, Vincent, Visuri, Vos, Walsh, Walsh, Weller, Widner, Wilson, Zheng   +108 more
core   +2 more sources

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

, 2018
Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim, Holtzman, David M, Ma, Qingyi, Owens, Nelly Chuqui, Sagare, Abhay P, Verghese, Philip B, Wang, Min, Wu, Yingxi, Zhao, Zhen, Zlokovic, Berislav V   +9 more
core   +3 more sources

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +1 more source