Results 61 to 70 of about 8,409 (135)

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury [PDF]

, 2018
The migration of polymorphonuclear granulocytes (PMN) into the brain parenchyma and release of their abundant proteases are considered the main causes of neuronal cell death and reperfusion injury following ischemia.
Beschorner, Rudi, Cheng, Yu-Jung, Dirnagl, Ulrich, Endres, Matthias, Engelhardt, Britta, Enzmann, Gaby, Ghavampour, Sharang, Gorina, Roser, Hannocks, Melanie-Jane, Harter, Patrick, Mittelbronn, Michel, Mysiorek, Caroline, Prinz, Marco, Prinz, Vincent, Sorokin, Lydia   +14 more
core  

Peripheral accumulation of newly produced T and B lymphocytes in natalizumab-treated multiple sclerosis patients [PDF]

, 2012
The anti-α4 monoclonal antibody natalizumab inhibits lymphocyte extravasation into the central nervous system and increases peripheral T and B lymphocytes in multiple sclerosis patients.
Alessandra Sottini, Bielekova, Cinzia Zanotti, Crowley, del Pilar Martin, Emirena Garrafa, Fabio Torri, Federico Serana, Fletcher, Gorelik, Hug, Ifergan, Kivisäkk, Kogan, Krumbholz, Laplaud, Lee, Luigi Caimi, Luisa Imberti, Lutterotti, Marco Chiarini, Muraro, Niino, Pittet, Planas, Polman, Putzki, Ruggero Capra, Ryan, Sarah Rasia, Sawada, Schwab, Serana, Skarica, Sottini, Sottini, Stüve, Takada, van Zelm, Wipfler, Ye, Zanotti, Zohren   +42 more
core   +1 more source

Foxc1 is required by pericytes during fetal brain angiogenesis [PDF]

, 2014
Summary Brain pericytes play a critical role in blood vessel stability and blood–brain barrier maturation. Despite this, how brain pericytes function in these different capacities is only beginning to be understood.
Choe, Youngshik, Daneman, Richard, Hsieh, Ivy, Huang, Eric J., Jaminet, Shou-Ching, Kume, Tsutomu, Li, Dan, Patterson, Katelin P., Pleasure, Samuel J., Siegenthaler, Julie A.   +9 more
core   +1 more source

Analysis of norepinephrine-regulated cerebral lymphatic drainage by the second near-infrared region in vivo imaging

APL Photonics
The cerebral lymphatic drainage plays an important role in the occurrence and development of central nervous system diseases. Recent studies have shown that cerebral lymphatic drainage is regulated by circadian rhythm and anesthesia state; however, the ...
Xi Li, Tianhao Yang, Zhongyang Zhang, Shengnan Wu, Zhen Yuan, Feifan Zhou   +5 more
doaj   +1 more source

The multiple faces of leukocyte interstitial migration

, 2014
Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in ...
Germain, R., Lämmermann, T.
core   +1 more source

dab2 is required for the scavenging function of lymphatic endothelial cells in the zebrafish meninges

Scientific Reports
To date it is only partially understood how the brain is cleared of waste products resulting from its high metabolic activity, although this process has important implications for the development and progression of neurodegenerative diseases.
Katharina Uphoff, Irina Suárez, Andreas van Impel, Stefan Schulte-Merker   +3 more
doaj   +1 more source

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Frontiers in Physiology, 2019
The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of
Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Virginia H. Huxley, Virginia H. Huxley, Virginia H. Huxley, Leike Xie, Filiz Bunyak, Kannappan Palaniappan, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky   +13 more
doaj   +1 more source

Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges

Frontiers in Cell and Developmental Biology
The brain has traditionally been considered an “immune-privileged” organ lacking a lymphatic system. However, recent studies have challenged this view by identifying the presence of the glymphatic system and meningeal lymphatic vessels (MLVs).
Rui Zhang, Jiuhong Li, Xueying Li, Si Zhang   +3 more
doaj   +1 more source

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2023
Guo X, Zhang G, Peng Q, Huang L, Zhang Z, Zhang Z.   +5 more
europepmc   +1 more source