Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions [PDF]
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni +8 more
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Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels [PDF]
Frontiers in Immunology, 2020 Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint +9 more
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A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice [PDF]
Nature Communications, 2022 The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
Weiping Dai +18 more
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Meningeal Lymphatics: An Immune Gateway for the Central Nervous System [PDF]
Cells, 2021 The recent (re)discovery of the meningeal lymphatic system has opened new theories as to how immune cells traffic and interact with the central nervous system (CNS).
Gabriel A. Tavares, Antoine Louveau
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Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease [PDF]
Molecular Neurodegeneration, 2023 Alzheimer’s disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain.
Shanon Rego +2 more
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Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo [PDF]
Communications BiologySystemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
L. Monet Roberts +10 more
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Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage [PDF]
Nature Communications, 2020 Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH ...
Jinman Chen +11 more
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Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI [PDF]
Fluids and Barriers of the CNS, 2023 The clearance pathways of brain waste products in humans are still under debate in part due to the lack of noninvasive imaging techniques for meningeal lymphatic vessels (mLVs).
Jun-Hee Kim +3 more
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Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]
Translational NeurodegenerationAdvancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng +6 more
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Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics [PDF]
Frontiers of Optoelectronics, 2023 With the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD ...
Semyachkina-Glushkovskaya Oxana +16 more
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