Results 21 to 30 of about 4,490 (191)

Meningeal lymphatics "drain" brain tumors. [PDF]

Cell Res, 2020
Kanamori M, Kipnis J.
europepmc   +4 more sources

Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery

iScience
Summary: The anatomical basis of cerebrospinal and interstitial fluid clearance along the human ventral meninges remains poorly defined. Here, we present the in vivo and ex vivo evidence of a distinct CSF-ISF drainage compartment surrounding the middle ...
Mehmet Albayram, Sutton B. Richmond, Kaan Yagmurlu, Ibrahim S. Tuna, Eda Karakaya, Hiranmayi Ravichandran, Fatih Tufan, Emal Lesha, Melike Mut, Filiz Bunyak, Yashar.S. Kalani, Adviye Ergul, Rachael D. Seidler, Onder Albayram   +13 more
doaj   +3 more sources

Meningeal lymphatics can influence stroke outcome. [PDF]

J Exp Med
Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this issue of JEM, Boisserand et al. (https://doi.org/10.1084/jem.20221983) provide evidence that expansion of meningeal lymphatics protects against ischemic stroke.
Koh GY, McDonald DM.
europepmc   +5 more sources

Meningeal Lymphatics in Central Nervous System Diseases. [PDF]

Annu Rev Neurosci
Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment ...
Salvador AFM, Abduljawad N, Kipnis J.
europepmc   +3 more sources

Meningeal lymphatics prime tumor immunity in glioblastoma. [PDF]

Cancer Cell, 2021
The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.
Graham MS, Mellinghoff IK.
europepmc   +3 more sources

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. [PDF]

J Clin Invest, 2017
Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J.   +5 more
europepmc   +3 more sources

Meningeal lymphatics in aging and Alzheimer's disease. [PDF]

Ann Transl Med, 2019
Recent research from the Kipnis laboratory (1-3) has highlighted the significance of meningeal lymphatics, which were originally identified in the dura mater of rat (4). These investigators underscored the crucial role of the meningeal lymphatics in brain immune surveillance and the clearance of metabolic wastes. They have also mapped out the path and
Jaffe RJ, Dave RS, Byrareddy SN.
europepmc   +3 more sources

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. [PDF]

Nature, 2021
Alzheimer's disease (AD) is the most prevalent cause of dementia1. Although there is no effective treatment for AD, passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) is a promising therapeutic strategy2,3. Meningeal lymphatic drainage has an important role in the accumulation of Aβ in the brain4, but it is not known whether ...
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS, Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J.   +30 more
europepmc   +4 more sources

Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow. [PDF]

J Neuroimmune Pharmacol, 2018
Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervical lymph nodes. In this letter, we highlighted the role of functional meningeal lymphatics and cerebrospinal fluid outflow.
Dave RS, Jain P, Byrareddy SN.
europepmc   +4 more sources

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

Frontiers in Pharmacology, 2021
A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita   +2 more
doaj   +1 more source