Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]
Acta Neuropathologica Communications, 2020 AbstractSubdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in the clearance of waste products in the ...
Xuanhui Liu +15 more
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Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity [PDF]
, 2017 No abstract ...
Habenicht, Andreas J.R. +3 more
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Lymphatic vessels of the dura mater: A new discovery? [PDF]
, 2015 Two recent paper s (Aspelund et al. 2015; Louveau et al. 2015) reported the presence in mice of lymphatics in the cerebra l dura mater , the most external of the meningeal layers covering the brain.
Bucchieri, F. +3 more
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CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature [PDF]
Nature Neuroscience, 2018 Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral ...
Antoine Louveau +20 more
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Spontaneous activity in peripheral diaphragmatic lymphatic loops. [PDF]
, 2013 The spontaneous contractility of FITC-dextran-filled lymphatics at the periphery of the pleural diaphragm was documented for the first time “in vivo” in anesthetized Wistar rats. We found that lymphatic segments could be divided into four phenotypes: 1)
Marcozzi C +3 more
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Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat [PDF]
, 2017 A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3–L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7–T8 vertebrae ...
Grau-Roma, Llorenc +5 more
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Impaired meningeal lymphatic vessel development worsens stroke outcome [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2019 The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) signaling for development.
Yanev, Pavel +8 more
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JCI Insight, 2022 The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF can
Yann Decker +6 more
doaj +1 more source
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
Frontiers in Neuroscience, 2022 The field of neuroimmunology endorses the involvement of the adaptive immune system in central nervous system (CNS) health, disease, and aging. While immune cell trafficking into the CNS is highly regulated, small numbers of antigen-experienced ...
Chiara Rickenbach, Christoph Gericke
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Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
, 2018 Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim +9 more
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