Results 51 to 60 of about 4,490 (191)

Mini review: Prospective therapeutic targets of Alzheimer's disease

Brain Circulation, 2022
Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease ...
RuchiMangal, YuchuanDing
doaj   +1 more source

Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. [PDF]

, 2023
BACKGROUND Routes along the olfactory nerves crossing the cribriform plate that extend to lymphatic vessels within the nasal cavity have been identified as a critical cerebrospinal fluid (CSF) outflow pathway.
Aleandri, Simone, Castillo, Alina, Cousin, Nikola, Detmar, Michael, Engelhardt, Britta, Kedracka, Anna, Luciani, Paola, Mapunda, Josephine A, Proulx, Steven T, Ries, Miriam, Spera, Irene, Vladymyrov, Mykhailo   +11 more
core   +1 more source

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

eLife, 2017
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich   +10 more
doaj   +1 more source

Established, New and Emerging Concepts in Brain Vascular Development

Frontiers in Physiology, 2021
In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran   +2 more
doaj   +1 more source

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders

Cell & Bioscience, 2022
In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even ...
Huimin Jiang, Huimin Wei, Yifan Zhou, Xuechun Xiao, Chen Zhou, Xunming Ji   +5 more
doaj   +1 more source

Fluid dynamics in aging-related dementias

Neurobiology of Disease, 2023
Recent human and animal model experimental studies revealed novel pathways for fluid movement, immune cell trafficking and metabolic waste clearance in CNS.
Thierno M. Bah, Dominic A. Siler, Aseel H. Ibrahim, Justin S. Cetas, Nabil J. Alkayed   +4 more
doaj   +1 more source

Meningeal lymphatic vessels regulate brain tumor drainage and immunity [PDF]

Cell Research, 2020
AbstractRecent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical lymph nodes (CLNs), and thus represent a potential therapeutic target for treating ...
Xueting Hu, Qiuping Deng, Lu Ma, Qingqing Li, Yidong Chen, Yuhan Liao, Fan Zhou, Chen Zhang, Linlin Shao, Jun Feng, Tubao He, Weihai Ning, Yan Kong, Yingqing Huo, Aibin He, Bing Liu, Jingjing Zhang, Ralf Adams, Yulong He, Fuchou Tang, Xiuwu Bian, Jincai Luo   +21 more
openaire   +2 more sources

The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans

Frontiers in Physiology, 2022
The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta, Jonah Sherbansky, Angela R. Kamer, Roxana O. Carare, Tracy Butler, Henry Rusinek, Gloria C. Chiang, Yi Li, Sara Strauss, L. A. Saint-Louis, Neil D. Theise, Richard A. Suss, Kaj Blennow, Michael Kaplitt, Mony J. de Leon   +14 more
doaj   +1 more source

Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. [PDF]

Nature, 2018
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route.
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J.   +22 more
europepmc   +4 more sources

The C–C chemokine receptor 7: An immune molecule that modulates central nervous system function in homeostasis and disease

Brain, Behavior, & Immunity - Health, 2023
The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya, Daniel Quintero, Devavani Chatterjea, Hannah Uttley, Colin Liphart, Zichen Tian, Elliot Yim, Fengping Hu   +7 more
doaj   +1 more source