Results 61 to 70 of about 4,490 (191)

Mapping meningeal vasculature in non-human primates

Veins and Lymphatics, 2022
Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson, Kyle Hauser, Scott Muller, Jeffrey H. Kordower, Liudmila Romanova   +4 more
doaj   +1 more source

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease

Journal of Alzheimer’s Disease, 2023
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into deep cervical lymph nodes.
Guo, Xiaodi, Zhang, Guoxin, Peng, Qinyu, Huang, Liqin, Zhang, Zhaohui, Zhang, Zhentao   +5 more
openaire   +2 more sources

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source

Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing [PDF]

, 2017
The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain.
Abdurashitov, Arkady, Bragin, Denis, Bragina, Olga, Bucharskaya, Alla, Dubrovsky, Alexander, Kurths, Jürgen, Maslyakova, Galina, Navolokin, Nikita, Semyachkina-Glushkovskaya, Oxana, Shirokov, Alexander, Shushunova, Natalia, Tuchind, Valery   +11 more
core   +1 more source

Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node

Frontiers in Immunology, 2018
A hallmark feature of follicular dendritic cells (FDCs) within the lymph nodes (LNs) is their ability to retain antigens and virions for a prolonged duration.
Rajnish S. Dave, Pooja Jain, Siddappa N. Byrareddy   +2 more
doaj   +1 more source

The Meningeal Lymphatic System: A New Player in Neurophysiology [PDF]

Neuron, 2018
The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer's disease (AD).
Sandro, Da Mesquita, Zhongxiao, Fu, Jonathan, Kipnis   +2 more
openaire   +2 more sources

Conserved meningeal lymphatic drainage circuits in mice and humans

Journal of Experimental Medicine, 2022
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained ...
Jacob, Laurent, de Brito Neto, Jose, Lenck, Stephanie, Corcy, Celine, Benbelkacem, Farhat, Geraldo, Luiz Henrique, Xu, Yunling, Thomas, Jean-Mickael, El Kamouh, Marie-Renee, Spajer, Myriam, Potier, Marie-Claude, Haik, Stephane, Kalamarides, Michel, Stankoff, Bruno, Lehericy, Stephane, Eichmann, Anne, Thomas, Jean-Leon   +16 more
openaire   +2 more sources

Por que usar agulhas atraumaticas em puncao lombar? [PDF]

, 2013
Diagnostic lumbar puncture is essential to the diagnosis of central nervous system infections, subarachnoid haemorrhage and others neurological diseases.
Matas, Sandro Luiz De Andrade
core   +3 more sources

Postnatal development of lymphatic vasculature in the brain meninges [PDF]

Developmental Dynamics, 2018
Background: Traditionally, the central nervous system (CNS) has been viewed as an immune‐privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull.
Rebecca M. Izen, Tomoko Yamazaki, Yoko Nishinaka‐Arai, Young‐Kwon Hong, Yoh‐Suke Mukouyama   +4 more
openaire   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source