Results 71 to 80 of about 4,490 (191)

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +1 more source

Literature review and meta-analysis of translaminar pressure difference in open-angle glaucoma [PDF]

, 2015
There is increasing evidence in the literature regarding translaminar pressure difference's (TPD) role in the pathophysiology of glaucoma. The optic nerve is exposed not only to intraocular pressure in the eye, but also to intracranial pressure (ICP), as
Bartusis, L., Daveckaite, A., Harris, A., Januleviciene, I., Kucinoviene, J., Ragauskas, A., Siaudvytyte, L., Siesky, B.   +7 more
core   +3 more sources

Waste Clearance in the Brain [PDF]

, 2021
Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning of all cerebrovascular and parenchymal brain cells.
Chopp, Michael, Davoodi-Bojd, Esmaeil, Ding, Guangliang, Fahmy, Lara M, Hu, Jiani, Jiang, Quan, Kaur, Jasleen, Zhang, Li, Zhang, Zhenggang   +8 more
core   +2 more sources

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Frontiers in Physiology, 2019
The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of
Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Virginia H. Huxley, Virginia H. Huxley, Virginia H. Huxley, Leike Xie, Filiz Bunyak, Kannappan Palaniappan, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky   +13 more
doaj   +1 more source

Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats

Frontiers in Pharmacology, 2023
Background: Fluids, solutes and immune cells have been demonstrated to drain from the brain and surrounding structures to the cervical lymph vessels and nodes in the neck via meningeal lymphatics, nasal lymphatics and/or lymphatic vessels associated with
Thu A. Hoang, Enyuan Cao, Gracia Gracia, Joseph A. Nicolazzo, Natalie L. Trevaskis   +4 more
doaj   +1 more source

Phototherapy of Alzheimer’s Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review [PDF]

, 2023
The global number of people with Alzheimer’s disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. However, pharmacological therapies for AD have failed to
Blokhina, Inna, Fedosov, Ivan, Kurths, Jürgen, Penzel, Thomas, Poluektov, Mikhail, Semyachkina-Glushkovskaya, Oxana, Sidorov, Victor, Terskov, Andrey, Tzoy, Maria   +8 more
core   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease

Acta Neuropathologica Communications, 2021
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high prevalence rate among the elderly population. A large number of clinical studies have suggested repetitive transcranial magnetic stimulation (rTMS) as a promising non-invasive ...
Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Lin   +9 more
doaj   +1 more source