Results 101 to 110 of about 37,289 (232)

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 2; peer review: 2 approved]

open access: yesF1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

open access: yesDrug Design, Development and Therapy, 2013
Dena Dorniani,1 Mohd Zobir bin Hussein,1 Aminu Umar Kura,2 Sharida Fakurazi,2 Abdul Halim Shaari,3 Zalinah Ahmad4 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Vaccines and Immunotherapeutics Laboratory ...
Dorniani D   +5 more
doaj  

Alpha 2 macroglobulin activity in rats infected with Trypanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease [PDF]

open access: yes, 2007
Background & objectives: Trypanosoma lewisi is a common, flagellated parasite of the rat. Ourprevious study showed that rabbits injected with serum collected from rats infected with Trypanosomalewisi and treated with cyclophosphamide (CyI) produced high ...
A. Budovsky, R. Sneir, E. Bazarsky & J. El-On
core  

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

open access: yesHaematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström   +10 more
doaj   +1 more source

Phytocorrection of Gastrointestinal Tract Structural Changes Caused by the Use of 6-Mercaptopurine

open access: yesАнтибиотики и Химиотерапия, 2020
It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.
YA. G. Razuvaeva   +4 more
doaj  

An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]

open access: yes, 2016
We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Baldacchino, Godfrey   +3 more
core  

Effect of Smart Pill Box on Improving Adherence to 6-Mercaptopurine Maintenance Therapy in Pediatric ALL

open access: yesIndian Journal of Medical and Paediatric Oncology
Introduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj   +1 more source

Some Perspectives on Immunosuppressive Drugs [PDF]

open access: yes, 1967
In conclusion, the antimetabolites have proven extremely interesting in the laboratory for the exploration of the mechanism of antibody synthesis and related problems.
Schwartz, Robert S.
core   +1 more source

Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants

open access: yesPediatric Research, 2020
Der-shiun Wang   +11 more
semanticscholar   +1 more source

Impact of 6-mercaptopurine and 6-mercaptopurine riboside on pro-inflammatory cytokines and oxidative stress in blood plasma of rats with complete Freund’s adjuvant (CFA) arthritis

open access: yesLife Sciences, Medicine and Biomedicine
Inflammatory arthritis is a chronic autoimmune disorder characterized by joint inflammation and pain, often requiring effective immunosuppressive treatment. In a rat model of inflammatory arthritis, the anti-immunosuppressive effects of 6-mercaptopurine
Che Ku Dahlan-Daud   +4 more
doaj   +1 more source

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