Results 11 to 20 of about 37,289 (232)

Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines [PDF]

OncoTarget, 2017
Polyphenols have been previously shown to sensitize leukemia cell lines to topoisomerase inhibitors. Here, we assess the effects of five polyphenols when used alone and in combination with antimetabolites: methotrexate, 6-mercaptopurine and 5 ...
Abels, Chandra, Cidlowski, D'Arca, Day, Domenicotti, Estrela, Hung, Jacqz-Aigrain, Jia, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Jordan-Mahy, Juillerat-Jeanneret, Krishnan, Ledwani, Lee, Lee, Li, Liang, Locasale, Lou, Manne, Mumper, Ni, Ong, Orlowski, Ramos, Rauko, Rodríguez-López, Scalbert, Schini-Kerth, Schmiegelow, Schönthal, Sharma, Singh, Sujatha, Tsao, Veit, Weng, Weng   +41 more
core   +2 more sources

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj   +2 more sources

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats

Saudi Pharmaceutical Journal, 2020
Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity.
Prem Kumar Govindappa, Darukeshwara Joladarashi, Raghavendra Lakshmana Shetty Hallur, Jagadeesh S. Sanganal, Ayyalasomayajula Ratna Phani   +4 more
doaj   +2 more sources

Langerhans Cell Histiocytosis Presenting With Diabetes Insipidus in a 2 Years Old Child: A Case Report. [PDF]

Clin Case Rep
ABSTRACT This case report highlights that Langerhans cell histiocytosis should be suspected in the differential diagnosis for children who exhibit failure to thrive, diabetes insipidus, and skin lesions. Early recognition and timely management are crucial for preventing irreversible hypothalamic–pituitary damage and improving outcomes.
Yohannes KG, Kassa NB, Tesso ZG, Digga AM.   +3 more
europepmc   +2 more sources

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment. [PDF]

Clin Transl Sci
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Khaeso K, Chainansamit SO, Kuwatjanakul P, Komvilaisak P, Nakkam N, Suwannaying K, Vannaprasaht S, Dornsena A, Tassaneeyakul W.   +8 more
europepmc   +2 more sources

Mercaptopurine for the Treatment of Ulcerative Colitis: A Randomized Placebo-Controlled Trial

Journal of Crohn's & Colitis, 2023
Background and Aims Scepticism about the efficacy of thiopurines for ulcerative colitis [UC] is rising. This study aimed to evaluate mercaptopurine treatment for UC.
M. Löwenberg, A. Volkers, S. van Gennep, A. Mookhoek, N. Montazeri, E. Clasquin, M. Duijvestein, A. V. van Bodegraven, S. Rietdijk, J. Jansen, D. V. van Asseldonk, E. P. van der Zanden, M. Dijkgraaf, R. West, N. D. de Boer, G. D'Haens   +15 more
semanticscholar   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench-To-Bedside Success Story in Thailand. [PDF]

Clin Transl Sci
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Biswas M, John S, Murad MA, Sukasem C.
europepmc   +2 more sources

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine

OncoTarget, 2021
Highly adaptable breast cancer cells that can opportunistically switch between proliferation and quiescence are often responsible for disease relapse. We have developed a function-based selection strategy for such resistant cells, exemplified by SUM149 ...
Balraj Singh, V. Sarli, A. Lucci
semanticscholar   +1 more source

Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia

JAMA Network Open, 2020
Key Points Question In children with acute lymphoblastic leukemia receiving oral mercaptopurine, can an intervention consisting of education and daily text message reminders to prompt directly supervised therapy result in a higher proportion of patients ...
S. Bhatia, L. Hageman, Yanjun Chen, F. L. Wong, Elizabeth L. McQuaid, Christina L. Duncan, Leo Mascarenhas, David R. Freyer, Nkechi I Mba, P. Aristizabal, D. Walterhouse, Glen Lew, Pamela Helen-Heilge Kempert, Thomas Bennett Russell, R. McNall-Knapp, S. Jacobs, H. Dang, E. Raetz, M. Relling, W. Landier   +19 more
semanticscholar   +1 more source

Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates

International Journal of Molecular Sciences, 2020
Flavonoids are natural phenolic compounds, which are the active ingredients in several dietary supplements. It is well-known that some flavonoid aglycones are potent inhibitors of the xanthine oxidase (XO)-catalyzed uric acid formation in vitro. However,
Violetta Mohos, Eszter Fliszár-Nyúl, M. Poór   +2 more
semanticscholar   +1 more source