Results 61 to 70 of about 37,289 (232)

Cyclophosphamide: An Alternative Treatment in Crohn’s Disease

Canadian Journal of Gastroenterology, 1989
lmmunosuppressive therapy in the form of 6-mercaptopurine has shown a 66% efficacy in severe, debilitating, highly corticosteroid dependent Crohn’s disease. Nevertheless this medication has some important side effects such as nausea, vomiting, leukopenia
Gilles Lapointe, Aubin Charbonneau
doaj   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]

, 2014
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P, Bonifazi, D, Bonifazi, F, Ceci, A, Chiron, C, Davies, E H, Eichler, I, Felisi, M, Giannuzzi, V, Giaquinto, C, Jacqz-Aigrain, E, Neubert, A, on behalf of the GRiP Consortium,, Pressler, R, Rabe, H, Ruggieri, L, Turner, M A, Whitaker, M J   +17 more
core   +1 more source

Phenotype, Management, and Outcomes in Paediatric Acute Pancreatitis: A Real‐Life Cross‐Sectional Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Limited Canadian data on paediatric acute pancreatitis exist. A meta‐analysis of 48 studies reported equal prevalence of acute pancreatitis among various aetiologies, with rates of severe acute pancreatitis at 13.7% in North America.
Catherine Korman, Doha Elhaoua, Sarah Blain, Thomas Li, Mariam Mohamed, Alessandro David, Colette Deslandres, Ugur Halac, Martha Dirks, Kelly Grzywacz, Michel Lallier, Fernando Alvarez, Prévost Jantchou   +12 more
wiley   +1 more source

The العلاقة بين التعدد الشكلي لجينة NUDT15 ذات الرقم ( rs116855232 ) والسمية النقوية المحرضة بمركبات البورين Mercaptopurine عند المرضى السوريين المشخص لديهم ابيضاض لمفاوي حاد

مجلة جامعة دمشق للعلوم الطبية, 2021
Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj  

The origin of clinical organ transplantation revisited [PDF]

, 2009
A patient whose illness had begun with edema and hypertension was found to have extreme atrophy of both kidneys. Because of the steady worsening of the condition and the appearance of uremia with other unfavorable diagnostic signs, transplantation of 1 ...
Barker, C, Starzl, TE
core   +1 more source

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia

Haematologica, 2016
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children[1][1]. Prolongation of therapy by incorporating a maintenance phase, containing 6-mercaptopurine (6-MP) as the backbone, has improved treatment outcomes in pediatric
Kanhatai Chiengthong, C. Ittiwut, Sasipa Muensri, J. Sophonphan, D. Sosothikul, P. Seksan, K. Suppipat, K. Suphapeetiporn, V. Shotelersuk   +8 more
semanticscholar   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Effect of Oral Allopurinol in Elevated Liver Enzyme Reduction in Pediatric Acute Lymphoblastic Leukemia During Maintenance Therapy

Novelty in Biomedicine
Background: Acute lymphoid leukemia (ALL) represents a prevalent form of cancer in pediatric populations. Mercaptopurine is one of the proposed treatments for these patients. This treatment may cause multiple side effects, including liver-related effects.
Parastoo Molaei Tavana, Nader Momtazmanesh, Ahmadreza Shamshiri, Zohre Jali   +3 more
doaj   +1 more source

Adalimumab‐responsive Monogenic Inflammatory Bowel Disease With Pseudopolyposis Characteristic of TGFBR2 Variant in Loeys‐Dietz Syndrome

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Loeys‐Dietz syndrome (LDS) is an autosomal dominant connective tissue disorder caused by pathogenic variants in TGFBR1 or TGFBR2. It is characterized by vascular fragility, skeletal abnormalities, and predisposition to allergic and inflammatory conditions, including monogenic inflammatory bowel disease (IBD).
Tomomitsu Sado, Satoshi Ukai, Shingo Kurasawa, Yosuke Kono, Norio Hasuda, Mai Iwaya, Takaya Nakane, Tomomi Yamaguchi, Tomoki Kosho, Yoshiko Nakayama   +9 more
wiley   +1 more source