Results 101 to 110 of about 5,177 (192)

Unmasking hidden Merkel cell carcinoma recurrences: Three illustrative cases of patients with rising viral oncoprotein antibody levels and challenge of requiring multi-modal imaging to detect clinical disease

Radiology Case Reports
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a high risk of recurrence and metastasis. Regular surveillance through physical exams and imaging studies is crucial for the timely detection of recurrences.
Nora A. Alexander, BS, Paul Nghiem, MD, PhD, Delphine L. Chen, MD, Song Y. Park, MD   +3 more
doaj   +1 more source

Updates in the Management of Merkel Cell Carcinoma

Brazilian Journal of Oncology, 2019
Merkel cell carcinomas are rare cutaneous malignancies with neuroendocrine features that affect elderly individuals with a history of chronic sun exposure and immunosuppression.
Paulo Henrique do Amor Divino, Gabriel Passos Souza, Maurício Fernando Silva-Almeida Ribeiro, George Horta, Fabíola Ambrosio Silveira-Lima, Alessandra Corte Real-Salgues, Rodrigo Ramella Munhoz   +6 more
doaj   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene-Targeted Therapies

Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer.
McMillan, Nigel AJ, Chokwassanasakulkit, Trairong   +1 more
core   +1 more source

A molecular case-control study of the Merkel cell polyomavirus in colon cancer.

, 2011
To explore the putative role of the Merkel cell polyomavirus in human colon cancer, a prospective molecular case-control study was undertaken in patients and their relatives enrolled during a screening program. Fresh tissue samples from 64 cases of colon
D'AGARO, PIERLANFRANCO, Minicozzi, Anna, CAMPELLO, CESARE, MINICOZZI, Annamaria, Comar M, POLI, Albino, RODELLA, LUCA, Poli A., Micozzi A, COMAR, Manola, Albino Poli, Cesare Campello, Manola Comar, D'Agaro P, Rondella L, Anna Minicozzi, Luca Rodella, Pierlanfranco D'Agaro   +17 more
core   +1 more source

Large T and small T antigens of Merkel cell polyomavirus

, 2015
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific
Moore, Patrick S., Chang, Yuan, Wendzicki, Justin A.   +2 more
core   +1 more source

Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts

mBio
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen, and ...
Joselyn Landazuri Vinueza, Nicholas J. H. Salisbury, Kristine N. Dye, Ann Roman, Denise A. Galloway   +4 more
doaj   +1 more source

Phosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus Replication

, 2014
Merkel Cell Polyomavirus (MCPyV) was recently discovered as a novel human polyomavirus that is associated with ~80% of Merkel Cell Carcinomas.
Xin Wang, Jianxin You, Sabrina Tsang, Jason Diaz, Jing Jiao   +4 more
core   +1 more source

Generation of Merkel cell polyomavirus (MCV)-like particles and their application to detection of MCV antibodies.

, 2010
The genome of a new human polyomavirus, known as Merkel cell polyomavirus (MCV), has recently been reported to be integrated within the cellular DNA of Merkel cell carcinoma (MCC), a rare human skin cancer.
S. Guyetant, Maxime Fleury, Nicolas Combelas, Annabel Maruani, Touz\ue9, Antoine, Baay, Marc, Coursaget, Pierre, Marc Baay, Antoine Touzé, Gaitan, Julien, Cazal, Rapha\uebl, Fleury, Maxime J., Pierre Yves Sizaret, Tognon, Mauro, Arnold, Françoise, M. Tognon, Raphaël Cazal, Pierre Coursaget, F. Arnold, R. Cazal, P.Y. Sizaret, Maruani, Annabel, P. Y. Sizaret, Touzé, Antoine, Arnold, Fran\ue7oise, Serge Guyetant, P. Coursaget, Julien Gaitan, Cazal, Raphaël, A. Maruani, A. Touzé, Françoise Arnold, Guyetant, Serge, Fleury, Maxime J J, M. J. Fleury, M. Baay, J. Gaitan, Combelas, Nicolas, Sizaret, Pierre-Yves, M. Fleury, N. Combelas   +40 more
core   +1 more source

Replication Data for: Comparative and integrated analyses of polyomavirus-negative and -positive Merkel cell carcinoma cell lines and their exosomes proteomic studies

, 2019
This dataset is analyses of identified proteins between MCPyV-negative (MCC13, MCC26, and UISO) and -positive (MKL1, MKL2, MS1, and WaGa) MCC cell line.Abstract: Proteomics have become an important tool in discovery and understanding pathological ...
Konstantinell, Aelita Gloria Virginia
core   +1 more source

Spontaneous remission of Merkel cell carcinoma presenting with tertiary lymphoid structures in an immunocompetent patient

Dermatology Reports
Dear Editor, Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer predominantly affecting elderly males, with a median age at diagnosis of 76 years.
Luigi Cerbone, Alessia Garau, Tiziana Borra, Paola Barbieri, Rebecca Parisi, Claudia Leporati, Marco Ghiglione, Federica Grosso   +7 more
doaj   +1 more source