Results 81 to 90 of about 7,231 (207)

Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes [PDF]

, 2016
It has long been hypothesized that polyomaviruses (PyV; family Polyomaviridae) codiverged with their animal hosts. In contrast, recent analyses suggested that codivergence may only marginally influence the evolution of PyV.
Akonkwa, DBM, Akoua-Koffi, C, Bergl, RA, Boesch, C, Calvignac-Spencer, S, Eckardt, W, Ehlers, B, Fruth, B, Gillespie, TR, Gray, M, Hohmann, G, Karhemere, S, Kujirakwinja, D, Langergraber, K, Leendertz, FH, Madinda, NF, Muyembe, J-J, Nishuli, R, Pauly, M, Peeters, M, Petrzelkova, KJ, Robbins, MM, Schubert, G, Stoinski, TS, Todd, A, Wertheim, JO, Wittig, RM, Zuberbuhler, K   +27 more
core   +2 more sources

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma [PDF]

JNCI: Journal of the National Cancer Institute, 2009
Merkel cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma.Multiplex antibody-binding assays were used to assess levels of ...
Carter, Joseph J., Paulson, Kelly G., Wipf, Greg C., Miranda, Danielle, Madeleine, Margaret M., Johnson, Lisa G., Lemos, Bianca D., Lee, Sherry, Warcola, Ashley H., Iyer, Jayasri G., Nghiem, Paul, Galloway, Denise A.   +11 more
openaire   +2 more sources

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas [PDF]

, 2014
Merkel cell carcinoma (MCC) is an aggressive, virus-associated, neuroendocrine tumor of the skin mainly affecting immunocompromised patients. Higher intratumoral infiltration with CD3 and CD8 positive T-cells is associated with a better prognosis ...
Behr, Daniel S., Dollt, Claudia, Goebeler, Matthias, Goerdt, Sergij, Hametner, Christian, Houben, Roland, Lasitschka, Felix, Marx, Alexander, Michel, Julia, Peitsch, Wiebke K., Schmieder, Astrid, Schönhaar, Kathrin   +11 more
core  

Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. [PDF]

PLoS ONE, 2015
Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated
Masahiro Shuda, Anna Guastafierro, Xuehui Geng, Yoko Shuda, Stephen M Ostrowski, Stefan Lukianov, Frank J Jenkins, Kord Honda, Stephen M Maricich, Patrick S Moore, Yuan Chang   +10 more
doaj   +1 more source

Vírus causadores de câncer e o papel da medicina laboratorial: revisão de literatura e perspectivas [PDF]

, 2013
Cancer-causing viruses are responsible for up to 20% of cancers with infectious etiology, representing a serious public health problem worldwide. Since the discovery of the first human cancer-causing virus, several others have been associated with ...
Granato, Celso Francisco Hernandes, Passos, Ana Maria   +1 more
core   +3 more sources

The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities

Human Mutation, Volume 2026, Issue 1, 2026.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou, Weili Chen, Liqin Ruan, Run Shi   +3 more
wiley   +1 more source

Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma [PDF]

International Journal of Cancer, 2013
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future MCC.
Helena, Faust, Kristin, Andersson, Johanna, Ekström, Maria, Hortlund, Trude Eid, Robsahm, Joakim, Dillner   +5 more
openaire   +2 more sources