Results 81 to 90 of about 4,032 (162)

Merkel Cell Polyomavirus and Cutaneous Merkel Cell Carcinoma [PDF]

Future Science OA, 2016
Minutilli, Ettore, Mulè, Antonino
openaire   +2 more sources

Updates in the Management of Merkel Cell Carcinoma

Brazilian Journal of Oncology, 2019
Merkel cell carcinomas are rare cutaneous malignancies with neuroendocrine features that affect elderly individuals with a history of chronic sun exposure and immunosuppression.
Paulo Henrique do Amor Divino, Gabriel Passos Souza, Maurício Fernando Silva-Almeida Ribeiro, George Horta, Fabíola Ambrosio Silveira-Lima, Alessandra Corte Real-Salgues, Rodrigo Ramella Munhoz   +6 more
doaj   +1 more source

Unmasking hidden Merkel cell carcinoma recurrences: Three illustrative cases of patients with rising viral oncoprotein antibody levels and challenge of requiring multi-modal imaging to detect clinical disease

Radiology Case Reports
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a high risk of recurrence and metastasis. Regular surveillance through physical exams and imaging studies is crucial for the timely detection of recurrences.
Nora A. Alexander, BS, Paul Nghiem, MD, PhD, Delphine L. Chen, MD, Song Y. Park, MD   +3 more
doaj   +1 more source

Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma

Virology, 2012
Merkel cell polyomavirus (MCPyV) is associated to Merkel cell carcinoma (MCC). We studied 113 MCC tumoral skin lesions originating from 97 patients. MCPyV detection was higher in fresh-frozen (FF) biopsies (94%) than in formalin-fixed paraffin-embedded biopsies (39-47%).
Martel-Jantin, Claire, Filippone, Claudia, Cassar, Olivier, Peter, M, Tomasic, Gorana, Vielh, Philippe, Brière, Josette, Petrella, Tony, Aubriot-Lorton, Marie-Hélène, Mortier, Laurent, Jouvion, Grégory, Sastre-Garau, Xavier, Robert, Caroline, Gessain, Antoine   +13 more
openaire   +2 more sources

Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts

mBio
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen, and ...
Joselyn Landazuri Vinueza, Nicholas J. H. Salisbury, Kristine N. Dye, Ann Roman, Denise A. Galloway   +4 more
doaj   +1 more source

Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis

The Journal of Clinical Investigation
Approximately 80% of Merkel cell carcinoma (MCC) cases are caused by Merkel cell polyomavirus (MCV), driven by its T antigen oncogene. Why MCV drives MCC, a skin cancer that displays the neuroendocrine Merkel cell phenotype, remains unclear.
Masahiro Shuda
doaj   +1 more source

Spontaneous remission of Merkel cell carcinoma presenting with tertiary lymphoid structures in an immunocompetent patient

Dermatology Reports
Dear Editor, Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer predominantly affecting elderly males, with a median age at diagnosis of 76 years.
Luigi Cerbone, Alessia Garau, Tiziana Borra, Paola Barbieri, Rebecca Parisi, Claudia Leporati, Marco Ghiglione, Federica Grosso   +7 more
doaj   +1 more source

Merkel Cell Polyomavirus role in Merkel Cell Carcinoma

, 2012
Nucleotidic sequences defining the genome of a new virus, the Merkel Cell Polyomavirus, has been discovered in 2008 in Merkel cell carcinoma, a rare form of cutaneous cancer developing mostly in immunosupressed individuals. Whereas this new virus belongs to the Polyomaviridae family, which includes known oncogenic viruses in animals, it was the first ...
openaire   +2 more sources

Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors. [PDF]

J Invest Dermatol, 2023
Weber M, Nguyen MB, Li MY, Flora P, Shuda M, Ezhkova E.   +5 more
europepmc   +1 more source

Merkel Cell Polyomavirus (MCPyV) and Cancers: Emergency Bell or False Alarm? [PDF]

Cancers (Basel), 2022
Dimitraki MG, Sourvinos G.
europepmc   +1 more source