Results 61 to 70 of about 7,231 (207)

Fruits of virus discovery: New pathogens and new experimental models [PDF]

, 2014
The advent of high-throughput sequencing has led to a tremendous increase in the rate of discovery of viral sequences. In some instances, novel pathogens have been identified.
Wang, David
core   +2 more sources

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, Volume 158, Issue 12, Page 3268-3278, 15 June 2026.
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

An Accurate Genetic Colocalisation Method for the HLA Locus

HLA, Volume 107, Issue 5, May 2026.
ABSTRACT Genetic colocalisation analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalisation is rarely undertaken at the HLA locus, due to its complex linkage disequilibrium (LD) and high polymorphism density.
Guillaume Butler‐Laporte, Tianyuan Lu, Sam Morris, Wenmin Zhang, Gavin Band, Fergus Hamilton, Amanda Chong, Kuang Lin, Ruth Nanjala, J. Brent Richards, Mei‐Hsuan Lee, Ling Yang, Pang Yao, Liming Li, Zhengming Chen, Yang Luo, Iona Y. Millwood, Robin G. Walters, Alexander J. Mentzer   +18 more
wiley   +1 more source

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters [PDF]

, 2014
Shaojie Zhang, Vojtech Sroller, Preeti Zanwar, Steven J. Halvorson, Nadim J. Ajami, Corey W. Hecksel, Jody L. Swain, Connie Wong, Janet S. Butel, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States
Ajami, Nadim J., Butel, Janet S., Chen, Chun Jung, Halvorson, Steven J., Hecksel, Corey W., Sroller, Vojtech, Sullivan, Christopher S., Swain, Jody L., Wong, Connie, Zanwar, Preeti, Zhang, Shaojie   +10 more
core   +7 more sources

Identification of Merkel cell polyomavirus in Merkel cell carcinoma tissue: case report of a Taiwanese patient

Dermatologica Sinica, 2010
Merkel cell carcinoma (MCC) is a rare malignancy with aggressive behavior mostly seen in the elderly and immunosuppressed patients. In 2008, the clonal integration of a new human polyomavirus, named Merkel cell polyomavirus (MCPyV), was found to be ...
Wen-Tsao Ho, Jonathan Te Peng Tseng, Chung-Hong Hu, Wei-Hwa Lee, Tsung-Hsien Tsai   +4 more
doaj   +1 more source

Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC

Viruses, 2022
Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke, Paul F. Lambert, Megan E. Spurgeon   +2 more
doaj   +1 more source

Merkel Cell Carcinoma and Immunosuppression, UV Radiation, and Merkel Cell Polyomavirus.

JAMA Dermatol
ImportanceMerkel cell carcinoma (MCC) is a rare but aggressive skin cancer. Quantifying the contribution of major potentially modifiable risk factors to the burden of MCC may inform prevention efforts.ObjectiveTo estimate the population attributable fraction of MCC cases in the US that were attributable to major immunosuppressing conditions (eg, HIV ...
Tribble JT, Pfeiffer RM, Brownell I, Cahoon EK, Sargen MR, Shiels MS, Luo Q, Cohen C, Drezner K, Hernandez B, Moreno A, Pawlish K, Saafir-Callaway B, Engels EA, Volesky-Avellaneda KD.   +14 more
europepmc   +3 more sources

Unexpected maspin immunoreactivity in Merkel cell carcinoma [PDF]

, 2015
Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous neuroendocrine tumor, which multifactorial etiopathogenesis seems to be related to ultraviolet radiation, Merkel cell polyomavirus (MCV), and immunosuppression.
Daniela Sala, Ioan Jung, Radu Mircea Neagoe, Sabin Gligore Turdean, Simona Gurzu   +4 more
core   +1 more source

Neoadjuvant therapy in skin cancer: current evidence and future perspectives

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 4, Page 454-462, April 2026.
Summary The development of immune checkpoint inhibitors and targeted therapies has fundamentally changed the treatment of cutaneous malignancies, especially in squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The latest neoadjuvant approaches have shown promising results in locally advanced stages.
Lea Daniello, Johannes Kleemann, Bastian Schilling   +2 more
wiley   +1 more source

Review on the role of the human Polyomavirus JC in the development of tumors [PDF]

, 2017
Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue.
Manola Comar, Pasquale Ferrante, Serena Delbue   +2 more
core   +1 more source