Results 61 to 70 of about 4,032 (162)

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Dermatology Practical & Conceptual, 2019
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a “cutaneous horn” on the face.
Brian A. Schick, Joshua S. Tobe, Mariamma G. Joseph, Tyler B. Rouse, Manal Y. Gabril   +4 more
doaj   +1 more source

Merkel Cell Carcinoma: A Complete Response to Avelumab Immunotherapy

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Merkel cell carcinoma is an aggressive form of cancer with poor prognosis, particularly for individuals deemed unsuitable for surgical resection. With new immunotherapy agents being used alone or as an adjuvant treatment, improving long term outcomes are being seen, even for those deemed to be treated with palliative intent.
Eamonn Byrne, Mel Corbett, Eoin Conlon, Fergal O'Duffy   +3 more
wiley   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma [PDF]

International Journal of Cancer, 2013
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future MCC.
Helena, Faust, Kristin, Andersson, Johanna, Ekström, Maria, Hortlund, Trude Eid, Robsahm, Joakim, Dillner   +5 more
openaire   +2 more sources

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma [PDF]

JNCI: Journal of the National Cancer Institute, 2009
Merkel cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma.Multiplex antibody-binding assays were used to assess levels of ...
Carter, Joseph J., Paulson, Kelly G., Wipf, Greg C., Miranda, Danielle, Madeleine, Margaret M., Johnson, Lisa G., Lemos, Bianca D., Lee, Sherry, Warcola, Ashley H., Iyer, Jayasri G., Nghiem, Paul, Galloway, Denise A.   +11 more
openaire   +2 more sources

Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. [PDF]

PLoS ONE, 2015
Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated
Masahiro Shuda, Anna Guastafierro, Xuehui Geng, Yoko Shuda, Stephen M Ostrowski, Stefan Lukianov, Frank J Jenkins, Kord Honda, Stephen M Maricich, Patrick S Moore, Yuan Chang   +10 more
doaj   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source