Results 41 to 50 of about 7,231 (207)

Human polyomaviruses in children undergoing transplantation, United States, 2008-2010 [PDF]

, 2012
Immunocompromised patients are at risk for disease caused by infection by some polyomaviruses. To define the prevalence of polyomaviruses in children undergoing transplantation, we collected samples from a longitudinal cohort and tested for the 9 known ...
Bauer, Irma, Canter, Charles, Hmiel, Paul, Holtz, Lori R, Lassa-Claxton, Sherry, Le, Binh-minh, Shenoy, Shalini, Shepherd, Ross, Siebrasse, Erica A, Sweet, Stuart, Turmelle, Yumirle, Wang, David   +11 more
core   +2 more sources

Merkel Cell Polyomavirus Infection and Detection [PDF]

Journal of Visualized Experiments, 2019
Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV molecular biology and oncogenic mechanisms have been hampered by a lack of adequate cell culture models.
Wei, Liu, Nathan A, Krump, Christopher B, Buck, Jianxin, You   +3 more
openaire   +2 more sources

Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

Journal of Skin Cancer, 2012
Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year.
T. Jaeger, J. Ring, C. Andres
doaj   +1 more source

Infectious Entry of Merkel Cell Polyomavirus [PDF]

Journal of Virology, 2018
MCPyV is the first polyomavirus directly implicated in the development of an aggressive human cancer, Merkel cell carcinoma (MCC). Although MCPyV is constantly shed from healthy skin, the MCC incidence increases among aging and immunocompromised individuals.
Becker, Miriam, Dominguez, Melissa, Greune, Lilo, Soria-Martinez, Laura, Pfleiderer, Moritz M., Schowalter, Rachel, Buck, Christopher B., Blaum, Bärbel S., Alexander Schmidt, M., Schelhaas, Mario   +9 more
openaire   +2 more sources

Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults

Emerging Infectious Diseases, 2009
Merkel cell polyomavirus (MCPyV) DNA was detected in 7 (1.3%) of 526 respiratory tract samples from patients in Australia with upper or lower respiratory tract symptoms.
Seweryn Bialasiewicz, Stephen B. Lambert, David M. Whiley, Michael D. Nissen, Theo P. Sloots   +4 more
doaj   +1 more source

Merkel cell polyomavirus is not detected in mesotheliomas [PDF]

Journal of Clinical Virology, 2010
Merkel cell polyomavirus (MCPyV) is the first polyoma virus consistently linked to the etiology of a human cancer. Serological studies indicate that the virus is commonly acquired in childhood, with seroprevalence reaching 50% or higher among young adults.
Kishor, Bhatia, Rama, Modali, James J, Goedert   +2 more
openaire   +2 more sources

Neurocan expression associates with better survival and viral positivity in Merkel cell carcinoma.

PLoS ONE, 2023
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that is frequently divided into Merkel cell polyomavirus negative and positive tumors due their distinct genomic and transcriptomic profiles, and disease outcomes.
Marko Salmikangas, Maria Laaksonen, Henrik Edgren, Marco Salgado, Anu Suoranta, Pirkko Mattila, Virve Koljonen, Tom Böhling, Harri Sihto   +8 more
doaj   +1 more source

Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain

Cells, 2023
Senescent cells accumulate in the host during the aging process and are associated with age-related pathogeneses, including cancer. Although persistent senescence seems to contribute to many aspects of cellular pathways and homeostasis, the role of ...
Alexander M. Pham, Luz E. Ortiz, Aron E. Lukacher, Hyun Jin Kwun   +3 more
doaj   +1 more source

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma [PDF]

, 2017
BACKGROUND: Distinct characteristic features categorize Merkel cell carcinoma (MCC) into two subgroups according to the Merkel cell polyomavirus infection.
Bohling, T., Kero, M., Knuutila, S., Koljonen, V., Sarhadi, Virinder Kaur, Veija, T.   +5 more
core   +1 more source

Virus-Induced Cancers of the Skin and Mucosa:Are We Dealing with "Smoking Guns" or "Smoke and Mirrors" in the Operating Theatre? [PDF]

, 2017
Introduction: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) is
A Gewirtzman, D Forman, H Feng, JM Garden, KG Paulson, L Calero, M Rioux, P Hallmo, PK Goon, PK Goon, RN Saladi, TL Diepgen, V Foulongne, WS Sawchuk, Y Chang, YL Tolstov   +15 more
core   +2 more sources