Results 21 to 30 of about 4,878,012 (192)

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis [PDF]

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj   +3 more sources

The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

Dermatologic Surgery, 2013
The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV.To review the role of MCV in MCC and its potential to influence diagnosis ...
Kyle, Amber, Michael P, McLeod, Keyvan, Nouri   +2 more
openaire   +3 more sources

Merkel Cell Polyomavirus role in Merkel Cell Carcinoma

, 2012
Nucleotidic sequences defining the genome of a new virus, the Merkel Cell Polyomavirus, has been discovered in 2008 in Merkel cell carcinoma, a rare form of cutaneous cancer developing mostly in immunosupressed individuals. Whereas this new virus belongs to the Polyomaviridae family, which includes known oncogenic viruses in animals, it was the first ...
Laude, Hélène
openaire   +3 more sources

Merkel cell polyomavirus and Langerhans cell neoplasm [PDF]

Cell Communication and Signaling, 2018
Background The relationship between various external agents such as pollen, food, and infectious agents and human sensitivity exists and is variable depending upon individual’s health conditions. For example, we believe that the pathogenetic potential of
Ichiro Murakami, Noriko Wada, Junko Nakashima, Mitsuko Iguchi, Makoto Toi, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Yasushi Horie, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert   +20 more
doaj   +3 more sources

Merkel Cell Polyomavirus and Merkel Cell Carcinoma, France

Emerging Infectious Diseases, 2008
To the Editor: Merkel cell carcinoma (MCC) is a primary cutaneous neuroendocrine tumor. This aggressive skin cancer is uncommon but increasing in frequency. During 1986–2001, incidence rate tripled; average annual increase was 8% (1). MCC shares epidemiologic features with Kaposi sarcoma, a malignant tumor associated with human herpesvirus 8 infection (
Vincent Foulongne, Nicolas Kluger, Olivier Dereure, Natalie Brieu, Bernard Guillot, Michel Segondy   +5 more
doaj   +3 more sources

Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Clinical and Therapeutic Perspectives

Seminars in Oncology, 2015
Merkel cell carcinoma (MCC) is a rare and often aggressive cutaneous cancer with a poor prognosis. The incidence of this cancer increases with age, immunodeficiency and sun exposure. Merkel cell polyomavirus (MCPyV), a new human polyomavirus identified in 2008, is detected in the majority of the MCCs and there is a growing body of evidence that healthy
Samimi-Gharaei, Mahtab, Gardair, Charlotte, Nicol, Jérôme, Arnold, Françoise, Touzé, Antoine, Coursaget, Pierre   +5 more
openaire   +4 more sources

Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]

J Med Virol
ABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S, Mariotti D, Messina S, Mazzotta V, Matusali G, Antinori A, Pietropaolo V, Maggi F, Rosa L.   +8 more
europepmc   +2 more sources

Epidemiology of Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma. [PDF]

Cancers (Basel), 2022
Merkel cell polyomavirus (MCPyV) is a ubiquitous virus replicating in human dermal fibroblasts. MCPyV DNA can be detected on healthy skin in 67–90% of various body sites, and intact virions are regularly shed from the skin. Infection occurs early in life, and seropositivity increases from 37 to 42% in 1- to 6-year-olds to 92% in adults.
Silling S, Kreuter A, Gambichler T, Meyer T, Stockfleth E, Wieland U.   +5 more
europepmc   +3 more sources

Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line. [PDF]

, 2020
Background - Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell
Moens, Ugo, Abdulsalam, Ibrahim Afolabi, Abdulsalam, Ibrahim, Rasheed, Kashif, Sveinbjørnsson, Baldur, Ehlers, Bernhard   +5 more
core   +1 more source

Merkel cell polyomavirus infection and Merkel cell carcinoma [PDF]

Current Opinion in Virology, 2016
Merkel cell polyomavirus is the only polyomavirus discovered to date that is associated with a human cancer. MCPyV infection is highly prevalent in the general population. Nearly all healthy adults asymptomatically shed MCPyV from their skin. However, in elderly and immunosuppressed individuals, the infection can lead to a lethal form of skin cancer ...
Wei, Liu, Margo, MacDonald, Jianxin, You
openaire   +2 more sources