Results 71 to 80 of about 5,177 (192)

Merkel cell carcinoma with seborrheic keratosis: A unique association

Indian Journal of Pathology and Microbiology, 2018
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk.
Murthy S Anand, Shantha Krishnamurthy, Suvarna Ravindranath, Jyothi Ranganathan   +3 more
doaj   +1 more source

Merkel Cell Carcinoma: A Complete Response to Avelumab Immunotherapy

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Merkel cell carcinoma is an aggressive form of cancer with poor prognosis, particularly for individuals deemed unsuitable for surgical resection. With new immunotherapy agents being used alone or as an adjuvant treatment, improving long term outcomes are being seen, even for those deemed to be treated with palliative intent.
Eamonn Byrne, Mel Corbett, Eoin Conlon, Fergal O'Duffy   +3 more
wiley   +1 more source

The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration

Virus Research, 2023
Recent studies have suggested that BK polyomavirus (BKPyV) may be associated with the development of urothelial carcinoma. In Merkel cell carcinoma, TAg and tAg are the major viral proteins of Merkel cell polyomavirus with oncogenic potential.
Jiun-Wen Wang, Yi-Jung Li, Hsin-Hsu Wu, Hsiang-Hao Hsu, Ming-Yang Chang, Robert YL Wang, Ya-Chung Tian   +6 more
doaj   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma [PDF]

JNCI: Journal of the National Cancer Institute, 2009
Merkel cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma.Multiplex antibody-binding assays were used to assess levels of ...
Carter, Joseph J., Paulson, Kelly G., Wipf, Greg C., Miranda, Danielle, Madeleine, Margaret M., Johnson, Lisa G., Lemos, Bianca D., Lee, Sherry, Warcola, Ashley H., Iyer, Jayasri G., Nghiem, Paul, Galloway, Denise A.   +11 more
openaire   +2 more sources

Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Dermatology Practical & Conceptual, 2019
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a “cutaneous horn” on the face.
Brian A. Schick, Joshua S. Tobe, Mariamma G. Joseph, Tyler B. Rouse, Manal Y. Gabril   +4 more
doaj   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

The Role of APOBEC3B in Cancer: Mechanisms, Clinical Challenges, and Therapeutic Opportunities

Human Mutation, Volume 2026, Issue 1, 2026.
Apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3B (APOBEC3B, A3B) is a key cytidine deaminase that induces genomic instability and clonal evolution in diverse malignancies. Although A3B plays a key role in the onset and advancement of various cancers, a comprehensive model bridging its multifaceted mechanisms and clinical translation ...
Fengfeng Zhou, Weili Chen, Liqin Ruan, Run Shi   +3 more
wiley   +1 more source

Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. [PDF]

PLoS ONE, 2015
Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated
Masahiro Shuda, Anna Guastafierro, Xuehui Geng, Yoko Shuda, Stephen M Ostrowski, Stefan Lukianov, Frank J Jenkins, Kord Honda, Stephen M Maricich, Patrick S Moore, Yuan Chang   +10 more
doaj   +1 more source