Results 71 to 80 of about 7,231 (207)

RNA‐Sequencing Reveals Two Subgroups of Eccrine Porocarcinomas and Poromas

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Eccrine porocarcinoma (EPC), a rare malignant eccrine gland tumour, remains molecularly understudied. Transcriptomic studies of EPC and benign eccrine poroma (EP) have identified recurrent fusions and expression changes, but differences distinguishing malignant EPC from benign EP are unclear.
Maya Puttonen, Sami Kilpinen, Maria von Willebrand, Kalle Ojala, Tom Böhling, Virve Koljonen, Harri Sihto   +6 more
wiley   +1 more source

RB1 inactivation in cutaneous carcinomas

Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv, Antoine Touzé, David Schrama, Serge Guyétant, Mahtab Samimi, Michael T Tetzlaff, Benjamin A Wood, Paul W Harms, Thibault Kervarrec   +8 more
wiley   +1 more source

Merkel Cell Carcinoma: The Past, the Present, and the Future

Journal of Skin Cancer, 2013
Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades.
Inamaria Erovic, Boban M. Erovic
doaj   +1 more source

Merkel cell carcinoma with seborrheic keratosis: A unique association

Indian Journal of Pathology and Microbiology, 2018
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk.
Murthy S Anand, Shantha Krishnamurthy, Suvarna Ravindranath, Jyothi Ranganathan   +3 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Murky Life of Merkel Cell Polyomavirus [PDF]

Cell Host & Microbe, 2016
Merkel cell polyomavirus (MCPyV) expressing viral T antigens is a common feature of most Merkel cell carcinomas, a primary neuroendocrine skin tumor. MCPyV has been difficult to propagate in vitro. In this issue of Cell Host & Microbe, Liu et al. (2016) report that human dermal fibroblasts support productive MCPyV infection.
openaire   +2 more sources

The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility [PDF]

, 2018
Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K⁺ and Cl⁻ channels now being ...
Adrian Whitehouse, Andrew Macdonald, Balkwill, Baquero-Pérez, Becker, Berrios, Feng, Fernández-Salas, G. Eric Blair, Gabrielė Stakaitytė, Griffiths, Harms, Hodgson, Houben, Houben, Hover, Huber, Hughes, Igloi, Jackson, Jamel Mankouri, James R. Boyne, Jiang, Jonathan D. Lippiat, Knight, Knips, Krzysztof Poterlowicz, Kwun, Lang, Li, Malik, Mao, McLaughlin-Drubin, Moens, Nnenna Nwogu, Peretti, Ritchie, Royle, Schumann, Shuda, Smith, Srinivasan, Stakaityt, Stakaityte, Starrett, Wang, Wheat, Yao, Zhao, Zheng   +49 more
core   +2 more sources

Merkel Cell Carcinoma: A Complete Response to Avelumab Immunotherapy

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Merkel cell carcinoma is an aggressive form of cancer with poor prognosis, particularly for individuals deemed unsuitable for surgical resection. With new immunotherapy agents being used alone or as an adjuvant treatment, improving long term outcomes are being seen, even for those deemed to be treated with palliative intent.
Eamonn Byrne, Mel Corbett, Eoin Conlon, Fergal O'Duffy   +3 more
wiley   +1 more source

Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Dermatology Practical & Conceptual, 2019
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a “cutaneous horn” on the face.
Brian A. Schick, Joshua S. Tobe, Mariamma G. Joseph, Tyler B. Rouse, Manal Y. Gabril   +4 more
doaj   +1 more source

The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration

Virus Research, 2023
Recent studies have suggested that BK polyomavirus (BKPyV) may be associated with the development of urothelial carcinoma. In Merkel cell carcinoma, TAg and tAg are the major viral proteins of Merkel cell polyomavirus with oncogenic potential.
Jiun-Wen Wang, Yi-Jung Li, Hsin-Hsu Wu, Hsiang-Hao Hsu, Ming-Yang Chang, Robert YL Wang, Ya-Chung Tian   +6 more
doaj   +1 more source