Results 91 to 100 of about 7,231 (207)

Merkel cell polyomavirus small T antigen mRNA level is increased following in vivo UV-radiation. [PDF]

PLoS ONE, 2010
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer involving Merkel cells. Recently, a new human polyomavirus was implicated in MCC, being present in 80% of the samples analyzed.
Ariane Mogha, Alain Fautrel, Nicolas Mouchet, Na Guo, Sébastien Corre, Henri Adamski, Eric Watier, Laurent Misery, Marie-Dominique Galibert   +8 more
doaj   +1 more source

Detection and quantification of classic and emerging viruses by skimmed-milk flocculation and PCR in river water from two geographical areas [PDF]

, 2013
Molecular techniques and virus concentration methods have shown that previously unknown viruses are shed by humans and animals, and may be transmitted by sewage-contaminated water.
Bofill Mas, S., Calgua, B., Fumian, T., Girones, R., Mbayed, Viviana Andrea, Miagostovich, M., Rodríguez Manzano, J., Rusinol, M.   +7 more
core   +1 more source

Prognostic Factors Influencing Oncologic Outcomes in Merkel Cell Carcinoma: A Retrospective Population‐Based Cohort Study

Journal of Skin Cancer, Volume 2026, Issue 1, 2026.
Aim/Objectives Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with a poorly understood etiology and lacking high‐level evidence to guide its management. This study examined the presentation and outcome related to MCC treatment at a Canadian center.
Megan McDonald, Vibhay Pareek, Frances-Claire Eichorn, Arbind Dubey, Alok Pathak, Richa Sharma   +5 more
wiley   +1 more source

Agnoprotein of polyomavirus BK interacts with proliferating cell nuclear antigen and inhibits DNA replication [PDF]

, 2015
License:Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein.
Barbara van Loon, Conny Tümmler, Elena Ferrari, Igor Snapkov, Mari Walquist, Mona Johannessen, Nancy Gerits, Sergiy Kostenko, Ugo Moens, Ulrich Hübscher   +9 more
core   +2 more sources

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges

Head &Neck, Volume 47, Issue 12, Page 3414-3428, December 2025.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Hunter A. Holley, Maria Lyons, Barry O'Sullivan, Neville Shine, Robbie Woods, Orla McArdle, James Paul O'Neill   +6 more
wiley   +1 more source

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

JEADV Clinical Practice, Volume 4, Issue 5, Page 1101-1113, December 2025.
Cutaneous squamous cell carcinoma (cSCC) exhibits a pro‐tumorigenic immune environment, increased oncologic signalling, and tumour remodelling, with three immune subgroups from ‘cold’ to ‘hot’. Organ transplant recipients (OTR) with cSCC showed reduced T‐cells and greater viral enrichment, especially HPV, and a higher disease burden.
Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan, Po Yin Tang, Tun Kiat Ko, Clara Wei Teng Koh, Kuan Rong Chan, Jason Yongsheng Chan   +8 more
wiley   +1 more source

The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer

Frontiers in Microbiology, 2018
Approximately 15–20% of human cancer is related to infection, which renders them potentially preventable by antimicrobial or antiviral therapy. Human polyomaviruses (PyVs) are relevant in this regard, as illustrated by the involvement of Merkel cell ...
Els van der Meijden, Mariet Feltkamp
doaj   +1 more source

A proteomic study of human Merkel Cell Carcinoma [PDF]

, 2013
Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cancer of the skin. The incidence has been quadrupled with a 5-year mortality rate of 46%, presently there is no cure for metastatic disease. Despite the contribution of Merkel cell polyomavirus,
Byrum, Stephanie D, Cornelius, Lynn A, Gao, Ling, Kannan, Aarthi, Lin, Zhenyu, Mackintosh, Samuel G, Moreland, Linley E, Morgan, Michael, Shao, Qiang, Stack, Brendan C, Jr, Tackett, Alan J   +10 more
core   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The Epidemiology of Neuroendocrine Carcinomas in Taiwan: A Population‐Based Cancer Registry Study

Cancer Medicine, Volume 14, Issue 21, November 2025.
Differences in the incidence trends and clinical outcomes of NECs suggest different etiologies and heterogeneities of NECs. Further investigations on risk factor identification and novel treatment strategies for NECs are warranted. ABSTRACT Background Lung and small cell neuroendocrine carcinomas (SCCs) are the most common sites and histological types ...
Yi‐Hsin Yang, Ru‐Yu Huang, Pei‐Yi Chu, Shuen‐Ru Yang, Jeng‐Shiun Du, Hui‐Jen Tsai   +5 more
wiley   +1 more source