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Epidemiology of Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma. [PDF]

Cancers (Basel), 2022
Merkel cell polyomavirus (MCPyV) is a ubiquitous virus replicating in human dermal fibroblasts. MCPyV DNA can be detected on healthy skin in 67–90% of various body sites, and intact virions are regularly shed from the skin. Infection occurs early in life, and seropositivity increases from 37 to 42% in 1- to 6-year-olds to 92% in adults.
Silling S, Kreuter A, Gambichler T, Meyer T, Stockfleth E, Wieland U.   +5 more
europepmc   +3 more sources

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma [PDF]

International Journal of Molecular Sciences, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has ...
Rotondo J. C., Mazziotta C., Lanzillotti C., Tognon M., Martini F.   +4 more
openaire   +3 more sources

Merkel cell polyomavirus infection and Merkel cell carcinoma [PDF]

Current Opinion in Virology, 2016
Merkel cell polyomavirus is the only polyomavirus discovered to date that is associated with a human cancer. MCPyV infection is highly prevalent in the general population. Nearly all healthy adults asymptomatically shed MCPyV from their skin. However, in elderly and immunosuppressed individuals, the infection can lead to a lethal form of skin cancer ...
Wei, Liu, Margo, MacDonald, Jianxin, You
openaire   +2 more sources

Merkel cell polyomavirus and Merkel cell carcinoma [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species.
openaire   +2 more sources

Merkel cell polyomavirus and Merkel cell carcinoma

Uirusu, 2009
A new polyomavirus, Merkel cell polyomavirus, was identified from Merkel cell carcinoma, a rare skin cancer. Origin of Merkel cell carcinoma is Merkel cell, a neuroendocrine cell in the skin. Merkel cell carcinoma occurs in the skin of head and face of white elders.
Tomoyuki, Nakamura, Harutaka, Katano
openaire   +3 more sources

Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma [PDF]

Modern Pathology, 2009
It has recently been shown that Merkel cell carcinoma, a rare and often lethal cutaneous malignancy, frequently harbors a novel clonally integrated polyomavirus aptly named Merkel cell polyomavirus. We aimed to study the prevalence of Merkel cell polyomavirus in cases of Merkel cell carcinoma, using specimens from formalin-fixed, paraffin-embedded ...
Eric J, Duncavage, Barbara A, Zehnbauer, John D, Pfeifer   +2 more
openaire   +2 more sources

Perforated gastric metastasis of Merkel cell carcinoma: Case report and review of the literature

Human Pathology: Case Reports, 2017
A 53 year-old Vietnamese male presented with a complaint of a left buttock mass which had grown to 8.0 cm during the past three years. A CT scan revealed the gluteal lesion and a large mass of the stomach.
Darshan Trivedi, MD, PhD, Victoria Collins, MD, Evans Roberts, MD, John Scopetta, MD, Tong Wu, MD, PhD, Byron Crawford, MD, Yukihiro Nakanishi, MD, PhD   +6 more
doaj   +1 more source

Identification of the neutralizing epitopes of Merkel cell polyomavirus major capsid protein within the BC and EF surface loops. [PDF]

PLoS ONE, 2015
Merkel cell polyomavirus (MCPyV) is the first polyomavirus clearly associated with a human cancer, i.e. the Merkel cell carcinoma (MCC). Polyomaviruses are small naked DNA viruses that induce a robust polyclonal antibody response against the major capsid
Maxime J J Fleury, Jérôme T J Nicol, Mahtab Samimi, Françoise Arnold, Raphael Cazal, Raphaelle Ballaire, Olivier Mercey, Hélène Gonneville, Nicolas Combelas, Jean-Francois Vautherot, Thierry Moreau, Gérard Lorette, Pierre Coursaget, Antoine Touzé   +13 more
doaj   +1 more source

Infectious Entry of Merkel Cell Polyomavirus [PDF]

Journal of Virology, 2018
MCPyV is the first polyomavirus directly implicated in the development of an aggressive human cancer, Merkel cell carcinoma (MCC). Although MCPyV is constantly shed from healthy skin, the MCC incidence increases among aging and immunocompromised individuals.
Becker, Miriam, Dominguez, Melissa, Greune, Lilo, Soria-Martinez, Laura, Pfleiderer, Moritz M., Schowalter, Rachel, Buck, Christopher B., Blaum, Bärbel S., Alexander Schmidt, M., Schelhaas, Mario   +9 more
openaire   +2 more sources

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma

mBio, 2017
Merkel cell polyomavirus is the primary etiological agent of the aggressive skin cancer Merkel cell carcinoma (MCC). Recent studies have revealed that UV radiation is the primary mechanism for somatic mutagenesis in nonviral forms of MCC.
Gabriel J. Starrett, Christina Marcelus, Paul G. Cantalupo, Joshua P. Katz, Jingwei Cheng, Keiko Akagi, Manisha Thakuria, Guilherme Rabinowits, Linda C. Wang, David E. Symer, James M. Pipas, Reuben S. Harris, James A. DeCaprio   +12 more
doaj   +1 more source