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Regulation of Polyomavirus Transcription by Viral and Cellular Factors
Viruses, 2020 Polyomavirus infection is widespread in the human population. This family of viruses normally maintains latent infection within the host cell but can cause a range of human pathologies, especially in immunocompromised individuals.
June F. Yang, Jianxin You
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Merkel Cell Polyomavirus Infection and Detection [PDF]
Journal of Visualized Experiments, 2019 Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV molecular biology and oncogenic mechanisms have been hampered by a lack of adequate cell culture models.
Wei, Liu +3 more
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BMC Endocrine Disorders, 2022 Background Vulvar neuroendocrine carcinomas with small cell morphology need an appropriate differential diagnosis with respect to primary Merkel cell carcinomas, primary small cell neuroendocrine carcinomas, and secondary/metastatic carcinomas.
Tomoko Hirakawa +4 more
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Journal of Skin Cancer, 2012 Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year.
T. Jaeger, J. Ring, C. Andres
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Merkel Cell Polyomavirus DNA in Respiratory Specimens from Children and Adults
Emerging Infectious Diseases, 2009 Merkel cell polyomavirus (MCPyV) DNA was detected in 7 (1.3%) of 526 respiratory tract samples from patients in Australia with upper or lower respiratory tract symptoms.
Seweryn Bialasiewicz +4 more
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Neurocan expression associates with better survival and viral positivity in Merkel cell carcinoma.
PLoS ONE, 2023 Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that is frequently divided into Merkel cell polyomavirus negative and positive tumors due their distinct genomic and transcriptomic profiles, and disease outcomes.
Marko Salmikangas +8 more
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Cells, 2023 Senescent cells accumulate in the host during the aging process and are associated with age-related pathogeneses, including cancer. Although persistent senescence seems to contribute to many aspects of cellular pathways and homeostasis, the role of ...
Alexander M. Pham +3 more
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Merkel cell carcinoma: epidemiology, clinical features, diagnosis and treatment of a rare disease
Anais Brasileiros de Dermatologia, 2023 Merkel cell carcinoma is a rare skin cancer with neuroendocrine differentiation. The risk factors include sun exposure, advanced age, immunosuppression (such as transplant recipients, patients with lymphoproliferative neoplasms, or patients with HIV ...
Stella Meireles Siqueira +4 more
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Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination
Viruses, 2020 Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
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Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma [PDF]
British Journal of Cancer, 2014 Prokineticin-1 (PROK1) and prokineticin-2 (PROK2) are chemokine-like proteins that may influence cancer growth by regulating host defence and angiogenesis. Their significance in viral infection-associated cancer is incompletely understood. We studied prokineticins in Merkel cell carcinoma (MCC), a skin cancer linked with Merkel cell polyomavirus (MCPyV)
Joensuu H. +11 more
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