Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome
Decreased fetal brain macrophages were previously reported in Ts1Cje mice, a model of Down syndrome (DS). We confirmed the reduction in primitive macrophages, brain macrophage precursors, using Ts1Cje‐derived mouse embryonic stem cells (Ts1Cje‐mESCs) and human induced pluripotent stem cells with trisomy 21 (Tri21‐hiPSCs), with in vivo validation ...
Koki Harada +9 more
wiley +1 more source
FOXI3 establishes the ectodermal niche in pharyngeal arches for cranial neural crest cells and their lineages. [PDF]
Chen X +17 more
europepmc +1 more source
The X Factor in Immunity: Sex Differences Shaped by the X Chromosome
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic +2 more
wiley +1 more source
DNA methylation as a biomarker of prenatal exposures: current challenges and opportunities. [PDF]
Walkup RB +3 more
europepmc +1 more source
A suture in time: The ontogeny of cranial suture morphology in mammals
Mammal cranial sutures are important indicators of the biomechanical and developmental pressures acting upon the skull. Across three prominent sutures dividing the vault of the mammalian skull, divergent patterns emerge both taxonomically and developmentally.
Heather E. White +4 more
wiley +1 more source
Left-right symmetry breaking: learning from the chicken. [PDF]
Pieper TK, Tsikolia N.
europepmc +1 more source
Cell and Gene Therapy in Equine Ocular Disease
ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young +2 more
wiley +1 more source
Differentiation properties of 3D scaffolds nanostructured with multi-walled carbon nanotubes on human induced pluripotent stem cells. [PDF]
Cavion F +6 more
europepmc +1 more source
ABSTRACT A 15‐week‐old Australian Labradoodle puppy was presented to The University of Queensland Small Animal Hospital for bilateral eyelid agenesis/coloboma and associated ocular complications. Enucleation of the left globe and repair of the right eyelid via a lip‐to‐lid transmucosal flap was performed. Given the subsequent development of prolapse of
Chi Hin Ng +4 more
wiley +1 more source
Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis. [PDF]
Haillot E +6 more
europepmc +1 more source

